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- W2783758839 abstract "The vascular smooth muscle cell (SMC) is one of the most plastic cells in the body. Understanding how non-coding RNAs (ncRNAs) regulate SMC cell-fate decision making in the vasculature has significantly enhanced our understanding of disease development, and opened up exciting new avenues for potential therapeutic applications. Recent studies on SMC physiology have in addition challenged our traditional view on their role and contribution to vascular disease, mainly in the setting of atherosclerosis as well as aneurysm disease, and restenosis after angioplasties. The impact of SMC behaviour on vascular disease is now recognized to be context dependent; SMC proliferation and migration can be harmful or beneficial, whereas their apoptosis, senescence, and switching into a more macrophage-like phenotype can promote inflammation and disease progression. This is in particular true for atherosclerosis-related diseases, where proliferation of SMCs was believed to promote lesion formation, but may also prevent plaque rupture by stabilizing the fibrous cap. Based on newer findings of genetic lineage tracing studies, it was revealed that SMC phenotypic switching can result in less-differentiated forms that lack classical SMC markers while exhibiting functions more related to macrophage-like cells. This switching can directly promote atherogenesis. The aim of this current review is to summarize and discuss how ncRNAs (mainly microRNAs and long ncRNAs) are involved in SMC plasticity, and how they directly affect vascular disease development and progression. Finally, we want to critically assess where potential future therapies could be useful to influence the burden of vascular diseases." @default.
- W2783758839 created "2018-01-26" @default.
- W2783758839 creator A5033406476 @default.
- W2783758839 creator A5038904980 @default.
- W2783758839 date "2017-12-29" @default.
- W2783758839 modified "2023-10-12" @default.
- W2783758839 title "Non-coding RNAs: key regulators of smooth muscle cell fate in vascular disease" @default.
- W2783758839 cites W144423133 @default.
- W2783758839 cites W1653019055 @default.
- W2783758839 cites W1799016756 @default.
- W2783758839 cites W1838133438 @default.
- W2783758839 cites W1847840776 @default.
- W2783758839 cites W1953646178 @default.
- W2783758839 cites W1964631913 @default.
- W2783758839 cites W1965030833 @default.
- W2783758839 cites W1965611576 @default.
- W2783758839 cites W1969204301 @default.
- W2783758839 cites W1972050299 @default.
- W2783758839 cites W1972104572 @default.
- W2783758839 cites W1975847255 @default.
- W2783758839 cites W1977279728 @default.
- W2783758839 cites W1978967539 @default.
- W2783758839 cites W1979322303 @default.
- W2783758839 cites W1990347775 @default.
- W2783758839 cites W1990459497 @default.
- W2783758839 cites W1996630410 @default.
- W2783758839 cites W1999812198 @default.
- W2783758839 cites W2004714113 @default.
- W2783758839 cites W2005406090 @default.
- W2783758839 cites W2005889517 @default.
- W2783758839 cites W2009872881 @default.
- W2783758839 cites W2014317512 @default.
- W2783758839 cites W2014346055 @default.
- W2783758839 cites W2014864029 @default.
- W2783758839 cites W2018621592 @default.
- W2783758839 cites W2027807256 @default.
- W2783758839 cites W2028555804 @default.
- W2783758839 cites W2031529022 @default.
- W2783758839 cites W2033602611 @default.
- W2783758839 cites W2033896075 @default.
- W2783758839 cites W2039816251 @default.
- W2783758839 cites W2040738170 @default.
- W2783758839 cites W2044586762 @default.
- W2783758839 cites W2044762564 @default.
- W2783758839 cites W2047493201 @default.
- W2783758839 cites W2050521206 @default.
- W2783758839 cites W2054542819 @default.
- W2783758839 cites W2055929468 @default.
- W2783758839 cites W2057805062 @default.
- W2783758839 cites W2058488557 @default.
- W2783758839 cites W2058835062 @default.
- W2783758839 cites W2059493282 @default.
- W2783758839 cites W2060737779 @default.
- W2783758839 cites W2063100614 @default.
- W2783758839 cites W2067452379 @default.
- W2783758839 cites W2070589498 @default.
- W2783758839 cites W2077548365 @default.
- W2783758839 cites W2085185881 @default.
- W2783758839 cites W2085220756 @default.
- W2783758839 cites W2087377443 @default.
- W2783758839 cites W2091445250 @default.
- W2783758839 cites W2093825335 @default.
- W2783758839 cites W2094940134 @default.
- W2783758839 cites W2096166765 @default.
- W2783758839 cites W2097767118 @default.
- W2783758839 cites W2098615353 @default.
- W2783758839 cites W2101987836 @default.
- W2783758839 cites W2102569350 @default.
- W2783758839 cites W2103566243 @default.
- W2783758839 cites W2105292164 @default.
- W2783758839 cites W2105349784 @default.
- W2783758839 cites W2107959716 @default.
- W2783758839 cites W2108661174 @default.
- W2783758839 cites W2111479290 @default.
- W2783758839 cites W2115268091 @default.
- W2783758839 cites W2117379522 @default.
- W2783758839 cites W2120156784 @default.
- W2783758839 cites W2124239182 @default.
- W2783758839 cites W2127770815 @default.
- W2783758839 cites W2128455103 @default.
- W2783758839 cites W2128940917 @default.
- W2783758839 cites W2130489491 @default.
- W2783758839 cites W2131736566 @default.
- W2783758839 cites W2132038259 @default.
- W2783758839 cites W2133863555 @default.
- W2783758839 cites W2135710731 @default.
- W2783758839 cites W2136324267 @default.
- W2783758839 cites W2137602565 @default.
- W2783758839 cites W2137840425 @default.
- W2783758839 cites W2139011620 @default.
- W2783758839 cites W2139274621 @default.
- W2783758839 cites W2139766730 @default.
- W2783758839 cites W2140723469 @default.
- W2783758839 cites W2142219773 @default.
- W2783758839 cites W2146104000 @default.
- W2783758839 cites W2146771915 @default.
- W2783758839 cites W2148239418 @default.
- W2783758839 cites W2148511255 @default.