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- W2783759267 abstract "Abstract Y14 (RBM8A) is an RNA recognition motif-containing protein that forms heterodimers with MAGOH and serves as a core factor of the RNA surveillance machinery for the exon junction complex (EJC). The role of the Y14 C-terminal serine/arginine (RS) repeat-containing region, which has been reported to undergo modifications such as phosphorylation and methylation, has not been sufficiently investigated. Thus, we aimed to explore the functional significance of the Y14 C-terminal region. Deletion or dephosphorylation mimic mutants of the C-terminal region showed a shift in localization from the nucleoplasmic region; in addition, the C-terminal RS repeat-containing sequence itself exhibited the potential for nucleolar localization. Additionally, the regulation of Y14 localization by the C-terminal region was further found to be exquisitely controlled by MAGOH binding. Cumulatively, our findings, which demonstrated that Y14 localization is regulated not only by the previously reported N-terminal localization signal but also by the C-terminal RS repeat-containing region through phosphorylation and MAGOH binding to Y14, provide new insights for the mechanism of localization of short RS repeat-containing proteins." @default.
- W2783759267 created "2018-01-26" @default.
- W2783759267 creator A5007207090 @default.
- W2783759267 creator A5056449434 @default.
- W2783759267 date "2018-01-12" @default.
- W2783759267 modified "2023-10-14" @default.
- W2783759267 title "C-terminal short arginine/serine repeat sequence-dependent regulation of Y14 (RBM8A) localization" @default.
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- W2783759267 doi "https://doi.org/10.1038/s41598-017-18765-1" @default.
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