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- W2783791422 abstract "Generally, an odt is a solid-dosage form that disintegrates and dissolves in the mouth (either on or beneath the tongue or in the buccal cavity) without water within 60 seconds or less. The us food and drug administration's center for drug evaluation and Research developed the following definition for an odt as a new dosage form in 1998 a solid dosage form containing medicinal substances, which disintegrates rapidly, Usually within a matter of seconds, when placed upon the tongue. The present study was carried out to develop a solid oral dosage form of Dextromethorphan HBr in the form of orally disintegrating tablet having pleasant taste and mouth feel that disintegrate within few seconds upon placing on tongue. Since Dextromethorphan HBr is extremely bitter, different techniques of taste masking were applied to reduce bitterness of drug and to get palatableformulation. The techniques used were ion-exchange resin complexation with Amberlite IRP64, inclusion complexation using cyclodextrin and adsorbate formation with magnesium trisilicate and ion exchange resin complexation which is simplest, efficient and cost effective is selected for further work. In present study, it is found that Amberllite IRP 64 can mask bitter taste of Dextromethorphan HBr by complex formation. Maximum drug loading is achieved using Amberlite IRP 64 and immediate drug release is achieved during dissolution study. DSC study shows complete complexation of Dextromethorphan- Amberlite IRP 64 complex prepared maintaining the pH of complexing medium at 8. Tablets prepared by direct compression are visually attractive, possess good mechanical strength with sufficient hardness. Targeted invitro disintegration time is achieved by using crospovidone as a superdisintegrant. Spray dried mannitol of SPI Pharma (Mannozem EZ) provides very good flow of the powder blend and excellent smooth mouthfeel has been experienced by volunteers. Mannitol contributes to the good taste of the formulation due to it’s cooling sensation in mouth." @default.
- W2783791422 created "2018-01-26" @default.
- W2783791422 creator A5041275318 @default.
- W2783791422 date "2014-04-01" @default.
- W2783791422 modified "2023-09-27" @default.
- W2783791422 title "Formulation and Evaluation of Orally Disintegrating Tablet of Taste Masked Drug" @default.
- W2783791422 hasPublicationYear "2014" @default.
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