Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783794897> ?p ?o ?g. }
Showing items 1 to 52 of
52
with 100 items per page.
- W2783794897 abstract "<p>Nature has been a rich source of pharmaceutical compounds, producing 80% of our currently prescribed drugs. The feijoa plant, Acca sellowiana, is classified in the family Myrtaceae, native to South America, and currently grown worldwide to produce feijoa fruit. Compounds with anticancer, anti-inflammatory, antibacterial and antifungal activities have been isolated from feijoa; however, the diversity of these compounds is not known nor is the mechanism of action of any of these compounds. I hypothesized that identifying compounds in novel feijoa cultivars would improve our understanding of the chemical diversity of antifungal compounds in feijoa and determining the antifungal mechanism of action of feijoa compounds would provide insight into the pharmaceutical potential of these compounds. First, GC-MS analyses were used to obtain an unbiased profile of 151 compounds from 16 cultivars of feijoa, of which six were novel cultivars. Multivariate analysis distinguished 18 compounds that were significantly and positively correlated to antifungal activity based on growth inhibition of Saccharomyces cerevisiae, of which seven had not previously been described from feijoa. Two novel cultivars were identified as the most bioactive cultivars, and the compound 4-cyclopentene-1,3-dione found in a couple of cultivars was potently antifungal against human pathogenic isolates of four Candida species. Second, chemical genetic analyses were used to investigate the mechanism of action of estragole, an antifungal compound previously isolated from feijoa. The chemical genetic profile of estragole was distinct from that of other known antifungal compounds, suggesting the mechanism of action of estragole has a novel antifungal mechanism. Third, chemical genetic analyses were used to investigate the mechanism of action of an ethanol adduct of vescalagin (EtOH-vescalagin) isolated from feijoa. We showed EtOH-vescalagin is antifungal against human pathogenic strains. Genome-wide chemical genetic analyses of EtOH-vescalagin indicated antifungal activity is mediated by disruptions of iron homeostasis, zinc homeostasis and retromer recycling through iron chelation. Overall, these results indicate the chemical and biological value of feijoa as a source of antifungal drugs.</p>" @default.
- W2783794897 created "2018-01-26" @default.
- W2783794897 creator A5078847907 @default.
- W2783794897 date "2021-11-23" @default.
- W2783794897 modified "2023-09-25" @default.
- W2783794897 title "Chemical genetic analyses of compounds derived from feijoa fruit" @default.
- W2783794897 doi "https://doi.org/10.26686/wgtn.17065334.v1" @default.
- W2783794897 hasPublicationYear "2021" @default.
- W2783794897 type Work @default.
- W2783794897 sameAs 2783794897 @default.
- W2783794897 citedByCount "0" @default.
- W2783794897 crossrefType "dissertation" @default.
- W2783794897 hasAuthorship W2783794897A5078847907 @default.
- W2783794897 hasBestOaLocation W27837948972 @default.
- W2783794897 hasConcept C185592680 @default.
- W2783794897 hasConcept C197321923 @default.
- W2783794897 hasConcept C2777278459 @default.
- W2783794897 hasConcept C2779294302 @default.
- W2783794897 hasConcept C2779548794 @default.
- W2783794897 hasConcept C556039675 @default.
- W2783794897 hasConcept C59822182 @default.
- W2783794897 hasConcept C71924100 @default.
- W2783794897 hasConcept C86803240 @default.
- W2783794897 hasConcept C89423630 @default.
- W2783794897 hasConceptScore W2783794897C185592680 @default.
- W2783794897 hasConceptScore W2783794897C197321923 @default.
- W2783794897 hasConceptScore W2783794897C2777278459 @default.
- W2783794897 hasConceptScore W2783794897C2779294302 @default.
- W2783794897 hasConceptScore W2783794897C2779548794 @default.
- W2783794897 hasConceptScore W2783794897C556039675 @default.
- W2783794897 hasConceptScore W2783794897C59822182 @default.
- W2783794897 hasConceptScore W2783794897C71924100 @default.
- W2783794897 hasConceptScore W2783794897C86803240 @default.
- W2783794897 hasConceptScore W2783794897C89423630 @default.
- W2783794897 hasLocation W27837948971 @default.
- W2783794897 hasLocation W27837948972 @default.
- W2783794897 hasOpenAccess W2783794897 @default.
- W2783794897 hasPrimaryLocation W27837948971 @default.
- W2783794897 hasRelatedWork W1969797342 @default.
- W2783794897 hasRelatedWork W2010345863 @default.
- W2783794897 hasRelatedWork W2178048341 @default.
- W2783794897 hasRelatedWork W2279762512 @default.
- W2783794897 hasRelatedWork W2316233610 @default.
- W2783794897 hasRelatedWork W2329615991 @default.
- W2783794897 hasRelatedWork W2496088822 @default.
- W2783794897 hasRelatedWork W2949750630 @default.
- W2783794897 hasRelatedWork W2952358103 @default.
- W2783794897 hasRelatedWork W3092768080 @default.
- W2783794897 isParatext "false" @default.
- W2783794897 isRetracted "false" @default.
- W2783794897 magId "2783794897" @default.
- W2783794897 workType "dissertation" @default.