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• W2783802064 abstract "// Fan Yang 1, 2, * , Qingjian Wu 3, * , Yan Zhang 1 , Haojun Xiong 1 , Xinzhe Li 1 , Bo Li 1 , Wei Xie 2 , Le Zhang 2 , Min Xu 4 , Kebin Zhang 2 and Fengtian He 1 1 Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Third Military Medical University, Chongqing 400038, China 2 Central Laboratory, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China 3 Department of Urology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China 4 Center for Disease Control and Prevention, Chengdu Military Region, Chengdu 610021, China * These authors have contributed equally to this work Correspondence to: Fengtian He, email: hefengtian66@163.com Kebin Zhang, email: zhangkebin12@163.com Min Xu, email: 603537726@qq.com Keywords: LOC653786; FOXM1; long noncoding RNA; renal cell carcinoma; cell growth Received: August 02, 2017      Accepted: January 02, 2018      Published: January 08, 2018 ABSTRACT Renal cell carcinoma (RCC) is the most common kidney malignancy with poor prognosis. Recently, long noncoding RNAs (lncRNAs) have been demonstrated as important regulators in multiple cancers including RCC. LOC653786 is a lncRNA, but its role in cancer remains unclear. In this study, we for the first time found that LOC653786 was upregulated in RCC tissues and cell lines, and this lncRNA promoted growth and cell cycle progression of RCC cells. Moreover, we showed that LOC653786 elevated the expression of forkhead box M1 (FOXM1) and its downstream target genes cyclin D1 and cyclin B1 in RCC cells. Reporter assay revealed that LOC653786 enhanced the transcriptional activity of FOXM1 gene promoter. Additionally, knockdown of FOXM1 attenuated the LOC653786-enhanced growth and cell cycle progression of RCC cells. Meanwhile, silencing of LOC653786 suppressed RCC cell growth and cell cycle progression, which was alleviated by overexpression of FOXM1. The in vivo experiments in nude mice showed knockdown of LOC653786 repressed xenograft tumor growth and FOXM1 expression. In conclusion, our results demonstrate that LOC653786 accelerates growth and cell cycle progression of RCC cells via upregulating FOXM1, suggesting that the ‘LOC653786/FOXM1’ pathway may serve as a novel target for RCC treatment." @default.
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• W2783802064 date "2018-01-08" @default.
• W2783802064 modified "2023-10-17" @default.
• W2783802064 title "LncRNA LOC653786 promotes growth of RCC cells via upregulating FOXM1" @default.
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• W2783802064 doi "https://doi.org/10.18632/oncotarget.24027" @default.
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