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• W2783804473 abstract "Endophenotypes and Research Domain Criteria (RDoC) represent recent efforts to deconvolute psychiatric illnesses into fundamental symptom clusters or biological markers more closely linked to genetic influences. By taking this one step farther, these biomarkers can be reduced to protophenotypes - endophenotypes conserved during evolution - with counterparts in lower organisms including <i>Caenorhabditis elegans</i> and <i>Drosophila</i>. Striking conservation in <i>C. elegans</i> of genes that increase the risk for mental illness bolsters the relevance of this model system for psychiatric research. Here, I review the characterization of several protophenotypes that are relevant for asociality, avolition/anhedonia, prepulse inhibition, and anorexia. Interestingly, the analogous behavioral defects in <i>C. elegans</i> are also corrected by psychotropic drugs used to treat the corresponding symptoms in man and/or are mediated by the same neurotransmitters. Overall, there is much we can learn about the complex human brain by studying simpler nervous systems directing evolutionarily conserved behaviors. The potential for generating important new insights from model organisms appears limitless when we begin to recognize the vestiges of evolution in ourselves." @default.
• W2783804473 created "2018-01-26" @default.
• W2783804473 creator A5087300079 @default.
• W2783804473 date "2017-01-01" @default.
• W2783804473 modified "2023-10-06" @default.
• W2783804473 title "Crossing the Worm-Brain Barrier by Using <b><i>Caenorhabditis elegans</i></b> to Explore Fundamentals of Human Psychiatric Illness" @default.
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• W2783804473 doi "https://doi.org/10.1159/000485423" @default.
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