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• W2783804817 abstract "<h3>Objectives:</h3> To identify the prevalence of carbapenem-resistant <i>Klebsiella pneumoniae</i> (CRKP) and the most common types of cabapenemases among CRKP in the Southern (Asir) province hospitals, Saudi Arabia. <h3>Methods:</h3> The cross-sectional study was conducted between late April and September in 2015. A total of 54 <i>Klebsiella pneumoniae (K. pneumoniae</i>) isolates with reduced sensitivity to carbapenems were obtained from various clinical specimens of the 2 largest hospitals in the Southern province. Minimum inhibitory concentrations (MICs) of carbapenems were confirmed using E-test. Molecular detection of the most common carbapenemase genes (blaIMP, <i>bla</i>-carbapenem-hydrolyzing oxacillinase [OXA-48], <i>bla</i>VIM, <i>bla</i>-New Delhi metallo-ß-lactamas [NDM], and <i>bla</i>KPC) was performed using multiplex-polymerase chain reaction. <h3>Results:</h3> The current study found that increasing age and intensive care unit admission were associated with CRKP isolation. The major type of carbapenemases was OXA-48 with 81.5% (n=44) and it seems to reach an endemic level. New Delhi metallo-ß-lactamas (NDM) was the second most frequent carbapenemase by 7.4% (n=4) of isolates while Verona integron-encoded metallo-ß-lactamase (VIM) was reported only in one isolate. <h3>Conclusion:</h3> Saudi Arabia receives large numbers of visitors and migrant workers from OXA-48 and NDM endemic countries such as Turkey, India, and Pakistan every year." @default.
• W2783804817 created "2018-01-26" @default.
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• W2783804817 date "2018-01-01" @default.
• W2783804817 modified "2023-10-16" @default.
• W2783804817 title "The emergence of carbapenem-resistant <i>Klebsiella pneumoniae</i> isolates producing OXA-48 and NDM in the Southern (Asir) province, Saudi Arabia" @default.
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• W2783804817 doi "https://doi.org/10.15537/smj.2018.1.21094" @default.
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