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- W2783805638 endingPage "913" @default.
- W2783805638 startingPage "870" @default.
- W2783805638 abstract "Abstract Hedgehog (Hh) signaling is an essential pathway in the human body, and plays a major role in embryo development and tissue patterning. Constitutive activation of the Hh signaling pathway through sporadic mutations or other mechanisms is explicitly associated with cancer development and progression in various solid malignancies. Therefore, targeted inhibition of the Hh signaling pathway has emerged as an attractive and validated therapeutic strategy for the treatment of a wide range of cancers. Vismodegib, a first‐in‐class Hh signaling pathway inhibitor was approved by the US Food and Drug Administration in 2012, and sonidegib, another potent Hh pathway inhibitor, received FDA's approval in 2015 as a new treatment of locally advanced or metastatic basal cell carcinoma. The clinical success of vismodegib and sonidegib provided strong support for the development of Hh signaling pathway inhibitors via targeting the smoothened (Smo) receptor. Moreover, Hh signaling pathway inhibitors aimed to target proteins, which are downstream or upstream of Smo, have also been pursued based on the identification of additional therapeutic benefits. Recently, much progress has been made in Hh singling and inhibitors of this pathway. Herein, medicinal chemistry strategies, especially the structural optimization process of different classes of Hh inhibitors, are comprehensively summarized. Further therapeutic potentials and challenges are also discussed." @default.
- W2783805638 created "2018-01-26" @default.
- W2783805638 creator A5042997502 @default.
- W2783805638 creator A5044174487 @default.
- W2783805638 creator A5044673310 @default.
- W2783805638 creator A5074162707 @default.
- W2783805638 creator A5086364214 @default.
- W2783805638 date "2018-01-05" @default.
- W2783805638 modified "2023-10-11" @default.
- W2783805638 title "Strategies to target the Hedgehog signaling pathway for cancer therapy" @default.
- W2783805638 cites W1258653530 @default.
- W2783805638 cites W1494543609 @default.
- W2783805638 cites W1497249052 @default.
- W2783805638 cites W1531790908 @default.
- W2783805638 cites W1554676002 @default.
- W2783805638 cites W1570224939 @default.
- W2783805638 cites W1942397261 @default.
- W2783805638 cites W1963807253 @default.
- W2783805638 cites W1964520746 @default.
- W2783805638 cites W1966269817 @default.
- W2783805638 cites W1969579048 @default.
- W2783805638 cites W1973133925 @default.
- W2783805638 cites W1979104257 @default.
- W2783805638 cites W1979685901 @default.
- W2783805638 cites W1979837082 @default.
- W2783805638 cites W1979855662 @default.
- W2783805638 cites W1980888416 @default.
- W2783805638 cites W1982269426 @default.
- W2783805638 cites W1984627030 @default.
- W2783805638 cites W1984999562 @default.
- W2783805638 cites W1985585069 @default.
- W2783805638 cites W1987213380 @default.
- W2783805638 cites W1989227091 @default.
- W2783805638 cites W1992280242 @default.
- W2783805638 cites W1992865216 @default.
- W2783805638 cites W1993064727 @default.
- W2783805638 cites W1996093708 @default.
- W2783805638 cites W1997186479 @default.
- W2783805638 cites W1997988878 @default.
- W2783805638 cites W1999907608 @default.
- W2783805638 cites W2000572318 @default.
- W2783805638 cites W2000827581 @default.
- W2783805638 cites W2001547088 @default.
- W2783805638 cites W2002418081 @default.
- W2783805638 cites W2006231917 @default.
- W2783805638 cites W2007333388 @default.
- W2783805638 cites W2007774407 @default.
- W2783805638 cites W2009147696 @default.
- W2783805638 cites W2010237337 @default.
- W2783805638 cites W2010515415 @default.
- W2783805638 cites W2010547317 @default.
- W2783805638 cites W2016444134 @default.
- W2783805638 cites W2016789175 @default.
- W2783805638 cites W2016876398 @default.
- W2783805638 cites W2016986240 @default.
- W2783805638 cites W2018001575 @default.
- W2783805638 cites W2019486264 @default.
- W2783805638 cites W2020079633 @default.
- W2783805638 cites W2020131167 @default.
- W2783805638 cites W2020968277 @default.
- W2783805638 cites W2024403989 @default.
- W2783805638 cites W2024838010 @default.
- W2783805638 cites W2025743781 @default.
- W2783805638 cites W2027605565 @default.
- W2783805638 cites W2030199762 @default.
- W2783805638 cites W2032904555 @default.
- W2783805638 cites W2033352055 @default.
- W2783805638 cites W2034215553 @default.
- W2783805638 cites W2036008273 @default.
- W2783805638 cites W2036199189 @default.
- W2783805638 cites W2036833206 @default.
- W2783805638 cites W2037876997 @default.
- W2783805638 cites W2039109621 @default.
- W2783805638 cites W2040182956 @default.
- W2783805638 cites W2041723754 @default.
- W2783805638 cites W2044799865 @default.
- W2783805638 cites W2045204046 @default.
- W2783805638 cites W2048851591 @default.
- W2783805638 cites W2050425010 @default.
- W2783805638 cites W2050569781 @default.
- W2783805638 cites W2051385741 @default.
- W2783805638 cites W2055296003 @default.
- W2783805638 cites W2055696756 @default.
- W2783805638 cites W2056041663 @default.
- W2783805638 cites W2056667375 @default.
- W2783805638 cites W2060087768 @default.
- W2783805638 cites W2060446790 @default.
- W2783805638 cites W2064938010 @default.
- W2783805638 cites W2065770215 @default.
- W2783805638 cites W2067933247 @default.
- W2783805638 cites W2069347490 @default.
- W2783805638 cites W2070073434 @default.
- W2783805638 cites W2074120188 @default.
- W2783805638 cites W2074466372 @default.
- W2783805638 cites W2076389391 @default.
- W2783805638 cites W2080423078 @default.
- W2783805638 cites W2080823574 @default.
- W2783805638 cites W2081170157 @default.