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- W2783827486 abstract "Human neuropeptide Y (hNPY) is one of the most widely expressed neurotransmitters in the human central and peripheral nervous systems. It consists of 36 highly conserved amino acid residues, and was first isolated from the porcine hypothalamus in 1982. While it is the most recently discovered member of the pancreatic polypeptide family (which includes neuropeptide Y, gut-derived hormone peptide YY, and pancreatic polypeptide), NPY is the most abundant peptide found in the mammalian brain. In order to exert particular functions, NPY needs to bind to the NPY receptor to activate specific signaling pathways. NPY receptors belong to the class A or rhodopsin-like G-protein coupled receptor (GPCR) family and signal via cell-surface receptors. By binding to GPCRs, NPY plays a crucial role in various biological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. Abnormal regulation of NPY is involved in the development of a wide range of diseases, including obesity, hypertension, atherosclerosis, epilepsy, metabolic disorders, and many cancers. Thus far, five receptors have been cloned from mammals (Y1, Y2, Y4, Y5, and y6), but only four of these (hY1, hY2, hY4, and hY5) are functional in humans. In this review, we summarize the structural characteristics of human NPY receptors and their role in metabolic diseases." @default.
- W2783827486 created "2018-01-26" @default.
- W2783827486 creator A5009121278 @default.
- W2783827486 creator A5032057886 @default.
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- W2783827486 creator A5075191597 @default.
- W2783827486 creator A5085217855 @default.
- W2783827486 date "2017-12-22" @default.
- W2783827486 modified "2023-10-16" @default.
- W2783827486 title "A Promising Therapeutic Target for Metabolic Diseases: Neuropeptide Y Receptors in Humans" @default.
- W2783827486 cites W1423028119 @default.
- W2783827486 cites W1510986852 @default.
- W2783827486 cites W1530842932 @default.
- W2783827486 cites W1551022035 @default.
- W2783827486 cites W1554003192 @default.
- W2783827486 cites W1578769003 @default.
- W2783827486 cites W1670847782 @default.
- W2783827486 cites W1774706107 @default.
- W2783827486 cites W1904610020 @default.
- W2783827486 cites W1937309249 @default.
- W2783827486 cites W1964443308 @default.
- W2783827486 cites W1964888317 @default.
- W2783827486 cites W1967015543 @default.
- W2783827486 cites W1967447656 @default.
- W2783827486 cites W1973460686 @default.
- W2783827486 cites W1976387438 @default.
- W2783827486 cites W1977034442 @default.
- W2783827486 cites W1985574462 @default.
- W2783827486 cites W1986349550 @default.
- W2783827486 cites W1987735575 @default.
- W2783827486 cites W1988628530 @default.
- W2783827486 cites W1990350561 @default.
- W2783827486 cites W1991051174 @default.
- W2783827486 cites W1995950505 @default.
- W2783827486 cites W1999508680 @default.
- W2783827486 cites W2000917313 @default.
- W2783827486 cites W2001796730 @default.
- W2783827486 cites W2004144873 @default.
- W2783827486 cites W2004400153 @default.
- W2783827486 cites W2005897231 @default.
- W2783827486 cites W2006001721 @default.
- W2783827486 cites W2006136492 @default.
- W2783827486 cites W2008682721 @default.
- W2783827486 cites W2009224618 @default.
- W2783827486 cites W2010945321 @default.
- W2783827486 cites W2011951708 @default.
- W2783827486 cites W2012155780 @default.
- W2783827486 cites W2014923981 @default.
- W2783827486 cites W2015301110 @default.
- W2783827486 cites W2015515690 @default.
- W2783827486 cites W2017790689 @default.
- W2783827486 cites W2019719068 @default.
- W2783827486 cites W2020874999 @default.
- W2783827486 cites W2025413785 @default.
- W2783827486 cites W2026431974 @default.
- W2783827486 cites W2026583794 @default.
- W2783827486 cites W2026982802 @default.
- W2783827486 cites W2028903713 @default.
- W2783827486 cites W2033550810 @default.
- W2783827486 cites W2033816024 @default.
- W2783827486 cites W2034079487 @default.
- W2783827486 cites W2039789253 @default.
- W2783827486 cites W2046271526 @default.
- W2783827486 cites W2046656052 @default.
- W2783827486 cites W2048025753 @default.
- W2783827486 cites W2050098144 @default.
- W2783827486 cites W2050839872 @default.
- W2783827486 cites W2051829755 @default.
- W2783827486 cites W2052790674 @default.
- W2783827486 cites W2053807193 @default.
- W2783827486 cites W2059588770 @default.
- W2783827486 cites W2060766383 @default.
- W2783827486 cites W2061870537 @default.
- W2783827486 cites W2062195112 @default.
- W2783827486 cites W2063608942 @default.
- W2783827486 cites W2064485294 @default.
- W2783827486 cites W2065230062 @default.
- W2783827486 cites W2067020358 @default.
- W2783827486 cites W2072112475 @default.
- W2783827486 cites W2073571766 @default.
- W2783827486 cites W2075044096 @default.
- W2783827486 cites W2078472278 @default.
- W2783827486 cites W2078948823 @default.
- W2783827486 cites W2079201209 @default.
- W2783827486 cites W2080650027 @default.
- W2783827486 cites W2080775361 @default.
- W2783827486 cites W2081377230 @default.
- W2783827486 cites W2081743030 @default.
- W2783827486 cites W2084287610 @default.
- W2783827486 cites W2084975523 @default.
- W2783827486 cites W2085792819 @default.
- W2783827486 cites W2087056848 @default.
- W2783827486 cites W2087301276 @default.
- W2783827486 cites W2088044480 @default.
- W2783827486 cites W2091685843 @default.
- W2783827486 cites W2093001303 @default.