FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783884669> ?p ?o ?g. }

• W2783884669 abstract "// Yong Liu 1,2 , Guiyang Wang 3 , Rui Huang 3 , Yingying Hao 4 , Haiyan Chang 3 , Chen Tian 3 , Yang Li 3 , Xiang-An Zhao 3 , Juan Xia 3 , Yuxin Chen 3,5 and Chao Wu 3 1 Department of Experimental Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China 2 Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, China 3 Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China 4 Department of Intensive Care Units, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China 5 Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China Correspondence to: Chao Wu, email: dr.wu@nju.edu.cn Yuxin Chen, email: yuxin_chen2015@163.com Keywords : PD-1; PD-L1; PD-L2; microenvironment; hepatitis B-related hepatocellular carcinoma Received: October 27, 2017     Accepted: December 05, 2017     Epub: January 12, 2018 Abstract 2 Dysregulated immune microenvironment, such as imbalance of programmed death-1 (PD-1) and its ligands (PD-Ls), plays a key role in hepatocarcinogenesis. Here we investigate the key immune checkpoint molecules, PD-1/PD-Ls, in liver tissues from patients with hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC). We show that the characteristic of T cells in peripheral blood does not fully reflect the changes of immune microenvironment in tumor tissues. There is an imbalanced immune microenvironment in liver tissues, characterized by increased CD4/CD8 ratio and high expression of PD-1 on CD8 T cells in tumor tissues. Soluble PD-1 (sPD-1) levels in tumor tissues are increased, whereas sPD-L1 and sPD-L2 levels are decreased. Compared with control subjects, the patients with HBV-related HCC have higher serum sPD-1 and sPD-L1 levels, lower serum sPD-L2 levels. We also show that the altered immune microenvironment is not only found in tumor tissues, but also in non-tumor tissues from HBV-related HCC patients. The correlation between PD-1 and PD-L1 increases successively in hepatocellular carcinomas tissues, paracancerous tissues and adjacent non-tumor tissues. In tumor tissues, sPD-1 levels are negatively correlated with clinicopathological stages of HCC, while serum sPD-L1 levels have positive correlation with the clinicopathological stages. Combined, HBV infection alone may not affect the characteristics of T cell subpopulations, but might be related with the higher PD-1 levels in liver tissues. The immune imbalance of PD-1/PD-Ls in liver tissues may have important role in tumor microenvironment and immune escape, closely related with tumor initiation and progression." @default.
• W2783884669 created "2018-01-26" @default.
• W2783884669 creator A5012657062 @default.
• W2783884669 creator A5013456366 @default.
• W2783884669 creator A5033080900 @default.
• W2783884669 creator A5034829045 @default.
• W2783884669 creator A5040234448 @default.
• W2783884669 creator A5046174516 @default.
• W2783884669 creator A5046594748 @default.
• W2783884669 creator A5053298239 @default.
• W2783884669 creator A5061140388 @default.
• W2783884669 creator A5068977419 @default.
• W2783884669 creator A5075740731 @default.
• W2783884669 date "2018-01-12" @default.
• W2783884669 modified "2023-09-27" @default.
• W2783884669 title "WITHDRAWN: Immune imbalance of PD-1 and 1 PD-Ls in liver tissues from patients with Hepatitis B-related hepatocellular carcinoma" @default.
• W2783884669 doi "https://doi.org/10.18632/oncotarget.24206" @default.
• W2783884669 hasPublicationYear "2018" @default.
• W2783884669 type Work @default.
• W2783884669 sameAs 2783884669 @default.
• W2783884669 citedByCount "0" @default.
• W2783884669 crossrefType "journal-article" @default.
• W2783884669 hasAuthorship W2783884669A5012657062 @default.
• W2783884669 hasAuthorship W2783884669A5013456366 @default.
• W2783884669 hasAuthorship W2783884669A5033080900 @default.
• W2783884669 hasAuthorship W2783884669A5034829045 @default.
• W2783884669 hasAuthorship W2783884669A5040234448 @default.
• W2783884669 hasAuthorship W2783884669A5046174516 @default.
• W2783884669 hasAuthorship W2783884669A5046594748 @default.
• W2783884669 hasAuthorship W2783884669A5053298239 @default.
• W2783884669 hasAuthorship W2783884669A5061140388 @default.
• W2783884669 hasAuthorship W2783884669A5068977419 @default.
• W2783884669 hasAuthorship W2783884669A5075740731 @default.
• W2783884669 hasBestOaLocation W27838846691 @default.
• W2783884669 hasConcept C126322002 @default.
• W2783884669 hasConcept C167672396 @default.
• W2783884669 hasConcept C17744445 @default.
• W2783884669 hasConcept C191935318 @default.
• W2783884669 hasConcept C199539241 @default.
• W2783884669 hasConcept C203014093 @default.
• W2783884669 hasConcept C2776107976 @default.
• W2783884669 hasConcept C2777382497 @default.
• W2783884669 hasConcept C2778019345 @default.
• W2783884669 hasConcept C71924100 @default.
• W2783884669 hasConcept C8891405 @default.
• W2783884669 hasConcept C90924648 @default.
• W2783884669 hasConceptScore W2783884669C126322002 @default.
• W2783884669 hasConceptScore W2783884669C167672396 @default.
• W2783884669 hasConceptScore W2783884669C17744445 @default.
• W2783884669 hasConceptScore W2783884669C191935318 @default.
• W2783884669 hasConceptScore W2783884669C199539241 @default.
• W2783884669 hasConceptScore W2783884669C203014093 @default.
• W2783884669 hasConceptScore W2783884669C2776107976 @default.
• W2783884669 hasConceptScore W2783884669C2777382497 @default.
• W2783884669 hasConceptScore W2783884669C2778019345 @default.
• W2783884669 hasConceptScore W2783884669C71924100 @default.
• W2783884669 hasConceptScore W2783884669C8891405 @default.
• W2783884669 hasConceptScore W2783884669C90924648 @default.
• W2783884669 hasIssue "5" @default.
• W2783884669 hasLocation W27838846691 @default.
• W2783884669 hasOpenAccess W2783884669 @default.
• W2783884669 hasPrimaryLocation W27838846691 @default.
• W2783884669 hasRelatedWork W2121914330 @default.
• W2783884669 hasRelatedWork W2324406516 @default.
• W2783884669 hasRelatedWork W2355632798 @default.
• W2783884669 hasRelatedWork W2356918548 @default.
• W2783884669 hasRelatedWork W2910019284 @default.
• W2783884669 hasRelatedWork W3030616408 @default.
• W2783884669 hasRelatedWork W3197243161 @default.
• W2783884669 hasRelatedWork W4281258761 @default.
• W2783884669 hasRelatedWork W4308976558 @default.
• W2783884669 hasRelatedWork W4360849283 @default.
• W2783884669 hasVolume "0" @default.
• W2783884669 isParatext "false" @default.
• W2783884669 isRetracted "false" @default.
• W2783884669 magId "2783884669" @default.
• W2783884669 workType "article" @default.