Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783886181> ?p ?o ?g. }
- W2783886181 endingPage "470" @default.
- W2783886181 startingPage "450" @default.
- W2783886181 abstract "Technological developments in gene editing raise high expectations for clinical applications, including editing of the germline. The European Society of Human Reproduction and Embryology (ESHRE) and the European Society of Human Genetics (ESHG) together developed a Background document and Recommendations to inform and stimulate ongoing societal debates. This document provides the background to the Recommendations. Germline gene editing is currently not allowed in many countries. This makes clinical applications in these countries impossible now, even if germline gene editing would become safe and effective. What were the arguments behind this legislation, and are they still convincing? If a technique could help to avoid serious genetic disorders, in a safe and effective way, would this be a reason to reconsider earlier standpoints? This Background document summarizes the scientific developments and expectations regarding germline gene editing, legal regulations at the European level, and ethics for three different settings (basic research, preclinical research and clinical applications). In ethical terms, we argue that the deontological objections (e.g., gene editing goes against nature) do not seem convincing while consequentialist objections (e.g., safety for the children thus conceived and following generations) require research, not all of which is allowed in the current legal situation in European countries. Development of this Background document and Recommendations reflects the responsibility to help society understand and debate the full range of possible implications of the new technologies, and to contribute to regulations that are adapted to the dynamics of the field while taking account of ethical considerations and societal concerns." @default.
- W2783886181 created "2018-01-26" @default.
- W2783886181 creator A5002298495 @default.
- W2783886181 creator A5012599511 @default.
- W2783886181 creator A5028575866 @default.
- W2783886181 creator A5029037934 @default.
- W2783886181 creator A5034141272 @default.
- W2783886181 creator A5037962041 @default.
- W2783886181 creator A5040936980 @default.
- W2783886181 creator A5060220786 @default.
- W2783886181 creator A5060918974 @default.
- W2783886181 creator A5062657695 @default.
- W2783886181 creator A5066162117 @default.
- W2783886181 creator A5077726256 @default.
- W2783886181 creator A5082707019 @default.
- W2783886181 creator A5089275994 @default.
- W2783886181 date "2018-01-12" @default.
- W2783886181 modified "2023-10-18" @default.
- W2783886181 title "Responsible innovation in human germline gene editing: Background document to the recommendations of ESHG and ESHRE" @default.
- W2783886181 cites W1541287046 @default.
- W2783886181 cites W1590831138 @default.
- W2783886181 cites W1826806098 @default.
- W2783886181 cites W1855058198 @default.
- W2783886181 cites W1895539995 @default.
- W2783886181 cites W1939279832 @default.
- W2783886181 cites W1974483110 @default.
- W2783886181 cites W1982831423 @default.
- W2783886181 cites W1983005863 @default.
- W2783886181 cites W1988643971 @default.
- W2783886181 cites W1989358863 @default.
- W2783886181 cites W1991247358 @default.
- W2783886181 cites W1995465696 @default.
- W2783886181 cites W2009746137 @default.
- W2783886181 cites W2014639769 @default.
- W2783886181 cites W2018217184 @default.
- W2783886181 cites W2022835856 @default.
- W2783886181 cites W2024275414 @default.
- W2783886181 cites W2026710705 @default.
- W2783886181 cites W2027952005 @default.
- W2783886181 cites W2032764699 @default.
- W2783886181 cites W2041468829 @default.
- W2783886181 cites W2050036034 @default.
- W2783886181 cites W2053860318 @default.
- W2783886181 cites W2058792860 @default.
- W2783886181 cites W2059145054 @default.
- W2783886181 cites W2063778214 @default.
- W2783886181 cites W2076958287 @default.
- W2783886181 cites W2077379243 @default.
- W2783886181 cites W2089929813 @default.
- W2783886181 cites W2091027511 @default.
- W2783886181 cites W2101529812 @default.
- W2783886181 cites W2111232767 @default.
- W2783886181 cites W2111589765 @default.
- W2783886181 cites W2136053894 @default.
- W2783886181 cites W2136609330 @default.
- W2783886181 cites W2140754284 @default.
- W2783886181 cites W2141825721 @default.
- W2783886181 cites W2151278369 @default.
- W2783886181 cites W2154253440 @default.
- W2783886181 cites W2156164053 @default.
- W2783886181 cites W2160704433 @default.
- W2783886181 cites W2161013638 @default.
- W2783886181 cites W2161604785 @default.
- W2783886181 cites W2167380395 @default.
- W2783886181 cites W2171915275 @default.
- W2783886181 cites W2189860642 @default.
- W2783886181 cites W2192836837 @default.
- W2783886181 cites W2203399982 @default.
- W2783886181 cites W2215413856 @default.
- W2783886181 cites W2230607819 @default.
- W2783886181 cites W226064163 @default.
- W2783886181 cites W2273649647 @default.
- W2783886181 cites W2281478543 @default.
- W2783886181 cites W2288757446 @default.
- W2783886181 cites W2296396974 @default.
- W2783886181 cites W2320086560 @default.
- W2783886181 cites W2330889352 @default.
- W2783886181 cites W2345388145 @default.
- W2783886181 cites W2345889524 @default.
- W2783886181 cites W2407256950 @default.
- W2783886181 cites W2409657603 @default.
- W2783886181 cites W2412655997 @default.
- W2783886181 cites W2484900834 @default.
- W2783886181 cites W2492028603 @default.
- W2783886181 cites W2507746105 @default.
- W2783886181 cites W2532813067 @default.
- W2783886181 cites W2556159813 @default.
- W2783886181 cites W2556243058 @default.
- W2783886181 cites W2583070206 @default.
- W2783886181 cites W2588855470 @default.
- W2783886181 cites W2597738633 @default.
- W2783886181 cites W2740810575 @default.
- W2783886181 cites W2772856878 @default.
- W2783886181 cites W2782671772 @default.
- W2783886181 cites W4207082673 @default.
- W2783886181 cites W4231070925 @default.
- W2783886181 cites W4235425475 @default.
- W2783886181 cites W4237400153 @default.