Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783897135> ?p ?o ?g. }
- W2783897135 abstract "Glycogen synthase kinase-3 (GSK-3) plays a critical role in cognitive dysfunction associated with Alzheimer’s disease (AD), yet the mechanism by which GSK-3 alters cognitive processes in other disorders, such as schizophrenia, remains unknown. In the present study, we demonstrated a role for GSK-3 in the direct regulation of neuronal oscillations in hippocampus (HIP) and prelimbic cortex (PL). A comparison of the GSK-3 inhibitors SB 216763 and lithium demonstrated disparate effects of the drugs on spatial memory and neural oscillatory activity in HIP and PL. SB 216763 administration improved spatial memory whereas lithium treatment had no effect. Analysis of neuronal local field potentials in anesthetized animals revealed that whereas both repeated SB 216763 (2.5 mg/kg) and lithium (100 mg/kg) induced a theta frequency spike in HIP at approximately 10 Hz, only SB 216763 treatment induced an overall increase in theta power (4-12 Hz) compared to vehicle. Acute administration of either drug suppressed slow (32-59 Hz) and fast (61-100 Hz) gamma power. In PL, both drugs induced an increase in theta power. Repeated SB 216763 increased HIP-PL coherence across all frequencies except delta, whereas lithium selectively suppressed delta coherence. These findings demonstrate that GSK-3 plays a direct role in the regulation of theta oscillations in regions critically involved in cognition, and highlight a potential mechanism by which GSK-3 may contribute to cognitive decline in disorders of cognitive dysfunction." @default.
- W2783897135 created "2018-01-26" @default.
- W2783897135 creator A5009077760 @default.
- W2783897135 creator A5055267590 @default.
- W2783897135 creator A5058760354 @default.
- W2783897135 creator A5071515787 @default.
- W2783897135 date "2018-01-12" @default.
- W2783897135 modified "2023-10-13" @default.
- W2783897135 title "Disparate Effects of Lithium and a GSK-3 Inhibitor on Neuronal Oscillatory Activity in Prefrontal Cortex and Hippocampus" @default.
- W2783897135 cites W1264856134 @default.
- W2783897135 cites W1483825698 @default.
- W2783897135 cites W1488890883 @default.
- W2783897135 cites W1537538750 @default.
- W2783897135 cites W1584535802 @default.
- W2783897135 cites W1598852457 @default.
- W2783897135 cites W1599930612 @default.
- W2783897135 cites W1607416079 @default.
- W2783897135 cites W1793903715 @default.
- W2783897135 cites W1857076555 @default.
- W2783897135 cites W1857269611 @default.
- W2783897135 cites W1941154838 @default.
- W2783897135 cites W1968620438 @default.
- W2783897135 cites W1968701523 @default.
- W2783897135 cites W1970774262 @default.
- W2783897135 cites W1972145246 @default.
- W2783897135 cites W1972196645 @default.
- W2783897135 cites W1973372728 @default.
- W2783897135 cites W1979612107 @default.
- W2783897135 cites W1979993283 @default.
- W2783897135 cites W1981420391 @default.
- W2783897135 cites W1981913961 @default.
- W2783897135 cites W1982499439 @default.
- W2783897135 cites W1985921148 @default.
- W2783897135 cites W1989771058 @default.
- W2783897135 cites W1991545546 @default.
- W2783897135 cites W1995540460 @default.
- W2783897135 cites W2002079862 @default.
- W2783897135 cites W2002337595 @default.
- W2783897135 cites W2004312953 @default.
- W2783897135 cites W2004377368 @default.
- W2783897135 cites W2005839666 @default.
- W2783897135 cites W2007047808 @default.
- W2783897135 cites W2007430976 @default.
- W2783897135 cites W2008093629 @default.
- W2783897135 cites W2009359796 @default.
- W2783897135 cites W2010301693 @default.
- W2783897135 cites W2017807006 @default.
- W2783897135 cites W2018951634 @default.
- W2783897135 cites W2019304821 @default.
- W2783897135 cites W2020034348 @default.
- W2783897135 cites W2020311418 @default.
- W2783897135 cites W2021479687 @default.
- W2783897135 cites W2023685957 @default.
- W2783897135 cites W2023826933 @default.
- W2783897135 cites W2028594041 @default.
- W2783897135 cites W2029960796 @default.
- W2783897135 cites W2035167862 @default.
- W2783897135 cites W2037681078 @default.
- W2783897135 cites W2038397615 @default.
- W2783897135 cites W2038669173 @default.
- W2783897135 cites W2039607980 @default.
- W2783897135 cites W2039795800 @default.
- W2783897135 cites W2045296415 @default.
- W2783897135 cites W2048622057 @default.
- W2783897135 cites W2048966304 @default.
- W2783897135 cites W2049146362 @default.
- W2783897135 cites W2051788298 @default.
- W2783897135 cites W2053053005 @default.
- W2783897135 cites W2053345504 @default.
- W2783897135 cites W2058459224 @default.
- W2783897135 cites W2064368529 @default.
- W2783897135 cites W2067102007 @default.
- W2783897135 cites W2067592930 @default.
- W2783897135 cites W2069175984 @default.
- W2783897135 cites W2074109817 @default.
- W2783897135 cites W2079010888 @default.
- W2783897135 cites W2079472896 @default.
- W2783897135 cites W2079945482 @default.
- W2783897135 cites W2080014250 @default.
- W2783897135 cites W2082932763 @default.
- W2783897135 cites W2084355781 @default.
- W2783897135 cites W2085176275 @default.
- W2783897135 cites W2085350184 @default.
- W2783897135 cites W2085968319 @default.
- W2783897135 cites W2088092325 @default.
- W2783897135 cites W2088645977 @default.
- W2783897135 cites W2089394160 @default.
- W2783897135 cites W2090139505 @default.
- W2783897135 cites W2091259368 @default.
- W2783897135 cites W2092446867 @default.
- W2783897135 cites W2094823371 @default.
- W2783897135 cites W2094832837 @default.
- W2783897135 cites W2095060637 @default.
- W2783897135 cites W2096891080 @default.
- W2783897135 cites W2098205950 @default.
- W2783897135 cites W2098985594 @default.
- W2783897135 cites W2099604930 @default.
- W2783897135 cites W2101356282 @default.
- W2783897135 cites W2101635884 @default.
- W2783897135 cites W2105966205 @default.