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• W2783916167 abstract "The use of matrix-assisted laser desorption/ionization, mass spectrometry imaging (MALDI MSI) has rapidly expanded, since this technique analyzes a host of biomolecules from drugs and lipids to N-glycans. Although various sample preparation techniques exist, detecting peptides from formaldehyde preserved tissues remains one of the most difficult challenges for this type of mass spectrometric analysis. For this reason, we have created and optimized a robust methodology that preserves the spatial information contained within the sample, while eliciting the greatest number of ionizable peptides. We have also aimed to achieve this in a cost effective and simple way, thereby eliminating potential bias or preparation error, which can occur when using automated instrumentation. The end result is a reproducible and inexpensive protocol." @default.
• W2783916167 created "2018-01-26" @default.
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• W2783916167 date "2018-01-16" @default.
• W2783916167 modified "2023-10-14" @default.
• W2783916167 title "Optimal Preparation of Formalin Fixed Samples for Peptide Based Matrix Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Workflows" @default.
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• W2783916167 doi "https://doi.org/10.3791/56778" @default.
• W2783916167 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5908653" @default.
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• W2783916167 hasPublicationYear "2018" @default.
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