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- W2783936726 endingPage "577" @default.
- W2783936726 startingPage "562" @default.
- W2783936726 abstract "Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common cutaneous T-cell lymphomas (CTCLs). Both lack curative options, and advanced-stage carries a poor prognosis. Whilst there are a number of treatments available, achieving and maintaining a durable remission remains challenging. We review current systemic treatment options as monotherapy for advanced-stage MF (IIB-IV), appraising their mechanism of action, analyzing their efficacy, and describing toxicities. Individually, reported overall response rates (ORR) vary widely in the literature and duration of responses are typically short, ranging from 7.5 to 22.4 months. Combined therapy is frequently used in an effort to boost responses, although prospective studies comparing combinations to single agent therapies are rarely conducted. While recent translational research has led to increased understanding of the immunopathogenesis of MF and SS and the development of new treatments, current standard of care therapies are not curative and have low ORR for advanced-stage disease." @default.
- W2783936726 created "2018-01-26" @default.
- W2783936726 creator A5012545681 @default.
- W2783936726 creator A5032142953 @default.
- W2783936726 creator A5032861872 @default.
- W2783936726 creator A5074283108 @default.
- W2783936726 date "2018-01-08" @default.
- W2783936726 modified "2023-09-24" @default.
- W2783936726 title "Current systemic therapeutic options for advanced mycosis fungoides and Sézary syndrome" @default.
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