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• W2783943185 abstract "Given that hearing ability can be challenged in diverse ways, it is necessary to develop an easily conducted, high-throughput method for assessing potential auditory risks. Measuring the acoustic startle response (ASR) has become a critical behavioral method in hearing research using zebrafish (Danio rerio). In this study, changes in the activity of zebrafish larvae (10 days post fertilization (dpf)) due to exposure to a sudden easily-generated broad-band noise were automatically and objectively recorded and analyzed without building sophisticated equipments. A significant increase in activity was induced by the noise stimulation and the alterations were impaired by gentamicin. In addition, a clear dose-response trend was observed between gentamicin exposure and the impaired activity, and a similar phenomenon was observed between gentamicin exposure and damage to hair cells. Our results suggested that alterations in the activity induced by a broad-band noise can potentially be used as an efficient assay for assessing hearing ability." @default.
• W2783943185 created "2018-01-26" @default.
• W2783943185 creator A5008081961 @default.
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• W2783943185 date "2018-03-01" @default.
• W2783943185 modified "2023-10-16" @default.
• W2783943185 title "Sound shock response in larval zebrafish: A convenient and high-throughput assessment of auditory function" @default.
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• W2783943185 doi "https://doi.org/10.1016/j.ntt.2018.01.003" @default.
• W2783943185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29330026" @default.
• W2783943185 hasPublicationYear "2018" @default.
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