Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783964825> ?p ?o ?g. }
- W2783964825 abstract "ABSTRACT Neurological and psychiatric diseases often involve the dysfunction of specific neural circuits in particular regions of the brain. Existing treatments, including drugs and implantable brain stimulators, aim to modulate the activity of these circuits, but are typically not cell type-specific, lack spatial targeting or require invasive procedures. Here, we introduce an approach to modulating neural circuits noninvasively with spatial, cell-type and temporal specificity. This approach, called acoustically targeted chemogenetics, or ATAC, uses transient ultrasonic opening of the blood brain barrier to transduce neurons at specific locations in the brain with virally-encoded engineered G-protein-coupled receptors, which subsequently respond to systemically administered bio-inert compounds to activate or inhibit the activity of these neurons. We demonstrate this concept in mice by using ATAC to noninvasively modify and subsequently activate or inhibit excitatory neurons within the hippocampus, showing that this enables pharmacological control of memory formation. This technology allows a brief, noninvasive procedure to make one or more specific brain regions capable of being selectively modulated using orally bioavailable compounds, thereby overcoming some of the key limitations of conventional brain therapies." @default.
- W2783964825 created "2018-01-26" @default.
- W2783964825 creator A5030593970 @default.
- W2783964825 creator A5042395452 @default.
- W2783964825 creator A5051459907 @default.
- W2783964825 creator A5075990359 @default.
- W2783964825 creator A5083995721 @default.
- W2783964825 date "2018-01-01" @default.
- W2783964825 modified "2023-10-14" @default.
- W2783964825 title "Acoustically Targeted Chemogenetics for Noninvasive Control of Neural Circuits" @default.
- W2783964825 cites W1934879953 @default.
- W2783964825 cites W1953231210 @default.
- W2783964825 cites W1965383030 @default.
- W2783964825 cites W1966403223 @default.
- W2783964825 cites W1972683821 @default.
- W2783964825 cites W1980363663 @default.
- W2783964825 cites W1989492845 @default.
- W2783964825 cites W1992898686 @default.
- W2783964825 cites W1996142593 @default.
- W2783964825 cites W1997732141 @default.
- W2783964825 cites W1999055090 @default.
- W2783964825 cites W1999772617 @default.
- W2783964825 cites W2003984876 @default.
- W2783964825 cites W2007362615 @default.
- W2783964825 cites W2008033906 @default.
- W2783964825 cites W2012799865 @default.
- W2783964825 cites W2015026123 @default.
- W2783964825 cites W2016117011 @default.
- W2783964825 cites W2019438546 @default.
- W2783964825 cites W2023916971 @default.
- W2783964825 cites W2026527241 @default.
- W2783964825 cites W2036632895 @default.
- W2783964825 cites W2043919363 @default.
- W2783964825 cites W2045821490 @default.
- W2783964825 cites W2052418484 @default.
- W2783964825 cites W2064886074 @default.
- W2783964825 cites W2066170543 @default.
- W2783964825 cites W2068597696 @default.
- W2783964825 cites W2069281265 @default.
- W2783964825 cites W2071815275 @default.
- W2783964825 cites W2071890828 @default.
- W2783964825 cites W2083748309 @default.
- W2783964825 cites W2084615691 @default.
- W2783964825 cites W2092920458 @default.
- W2783964825 cites W2094091345 @default.
- W2783964825 cites W2103217718 @default.
- W2783964825 cites W2103225095 @default.
- W2783964825 cites W2108503101 @default.
- W2783964825 cites W2109794373 @default.
- W2783964825 cites W2115362657 @default.
- W2783964825 cites W2117400459 @default.
- W2783964825 cites W2127833933 @default.
- W2783964825 cites W2131358222 @default.
- W2783964825 cites W2141410846 @default.
- W2783964825 cites W2151749347 @default.
- W2783964825 cites W2152233647 @default.
- W2783964825 cites W2154069299 @default.
- W2783964825 cites W2157475463 @default.
- W2783964825 cites W2176154815 @default.
- W2783964825 cites W2177217209 @default.
- W2783964825 cites W2226404073 @default.
- W2783964825 cites W2256579886 @default.
- W2783964825 cites W2275148408 @default.
- W2783964825 cites W2480227888 @default.
- W2783964825 cites W2492528640 @default.
- W2783964825 cites W2513805643 @default.
- W2783964825 cites W2517769867 @default.
- W2783964825 cites W2556360882 @default.
- W2783964825 cites W2573609557 @default.
- W2783964825 cites W2745223669 @default.
- W2783964825 cites W2765253110 @default.
- W2783964825 cites W2775538622 @default.
- W2783964825 cites W2810668771 @default.
- W2783964825 cites W2951288914 @default.
- W2783964825 cites W4241136696 @default.
- W2783964825 doi "https://doi.org/10.1101/241406" @default.
- W2783964825 hasPublicationYear "2018" @default.
- W2783964825 type Work @default.
- W2783964825 sameAs 2783964825 @default.
- W2783964825 citedByCount "2" @default.
- W2783964825 countsByYear W27839648252018 @default.
- W2783964825 crossrefType "posted-content" @default.
- W2783964825 hasAuthorship W2783964825A5030593970 @default.
- W2783964825 hasAuthorship W2783964825A5042395452 @default.
- W2783964825 hasAuthorship W2783964825A5051459907 @default.
- W2783964825 hasAuthorship W2783964825A5075990359 @default.
- W2783964825 hasAuthorship W2783964825A5083995721 @default.
- W2783964825 hasBestOaLocation W27839648251 @default.
- W2783964825 hasConcept C112592302 @default.
- W2783964825 hasConcept C118403218 @default.
- W2783964825 hasConcept C169760540 @default.
- W2783964825 hasConcept C17077164 @default.
- W2783964825 hasConcept C2781161787 @default.
- W2783964825 hasConcept C3018998897 @default.
- W2783964825 hasConcept C41008148 @default.
- W2783964825 hasConcept C86803240 @default.
- W2783964825 hasConceptScore W2783964825C112592302 @default.
- W2783964825 hasConceptScore W2783964825C118403218 @default.
- W2783964825 hasConceptScore W2783964825C169760540 @default.
- W2783964825 hasConceptScore W2783964825C17077164 @default.