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- W2783970947 abstract "The present study was to formulate and evaluatemicroencapsulated controlled release preparations of Zidovudine usingethyl cellulose as the retardant material with high entrapment efficiencyand extended release. Ethylcellulose is a natural, biodegradable polymerand the method adopted for preparing microsphere was water-in-oil-in-oil(w/o/o) double emulsion solvent diffusion technique. Novel drug delivery system is finding more attention inpharmaceutical industries due to its various advantages. In the linesustained/controlled release formulations are more focused for improvingthe drug bioavailability with less dosing frequency. Zidovudine is one suchcompound having a poor bioavailability with high dosing frequency. Thepresent investigation is focused to develop a suitable sustained releaseformulation for achieving better bioavailability and reduce dosingfrequency. Zidovudine was formulated as microspheres using ethylcellulose.Compatibility studies were carried out using FTIR. The results suggest noevidence of any interaction. Different batches containing variousconcentrations of drug, polymer with varying volume of dispersion mediumwas prepared by double emulsion solvent diffusion technique. The in vitro release suggest that low volume of dispersion mediumand low polymer ratio 64.05% of release at the end of 24 hrswith 65.12 % entrapment. It is evident that zidovudine loaded ethylcellulose microspheresshowed better sustained release profile which is up to 24 hrs. Theprepared formulation can be further evaluated to achieve a betterbioavailability. IN VIVO studies can be carried out to optimize theZidovudine microspheres using ethyl cellulose. The pharmacokineticbehavior of the formulated microspheres can be studies for optimization ofthe formulation." @default.
- W2783970947 created "2018-01-26" @default.
- W2783970947 creator A5025971988 @default.
- W2783970947 date "2009-03-01" @default.
- W2783970947 modified "2023-09-27" @default.
- W2783970947 title "Formulation and in Vitro Evaluation of ZidovudineMicrospheres" @default.
- W2783970947 hasPublicationYear "2009" @default.
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