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- W2783982632 abstract "The objective of this research work was to formulate, develop and evaluate combination of immediate release (IR) tablets of Tenofovir DF and Lamivudine. Tenofovir DF and Lamivudine are nucleotide and nucleoside reverse transcriptase inhibitor. These drugs have to be given in combination otherwise HIV virus develops resistance to these drugs.The tablets were prepared by dry granulation and wet granulation method. For the Immediate release formulation the disintegration time of the tablet must be optimised in order to have a faster release of drug in the dissolution profile. The disintegration time is managed by using the superdisintegrants like Croscarmellose sodium, sodium starch glycolate Type A in the formulation. The formulation trials were optimised by incorporating varying composition of Lactose monohydrate, microcrystalline cellulose as diluents, Croscarmellose sodium, Sodiumstarch glycolate Type-A as Superdisintegrants, Pregelatinized starch as binder, Magnesium stearate as lubricant. When the two drugs are combined the percentage release of the drugs was not matching with the innovator samples. So it was formulated as film coated immediate release bilayered tablets. The preformulation parameters such as bulk density, tapped density, compressibility index and hausner’s ratio were analysed for prepared granules before compression. The thickness, hardness, friability, weight variation, disintegration time and drug content uniformity was evaluated for core and coated tablets. The In-Vitro drug release studied were performed in the USP Apparatus-II (Paddle) using 0.1N HCl as a dissolution media at 50rpm speed and temperature of 37°c ± 0.5°c. The % drug release at different timeinterval was estimated using UV method. Based on the evaluation result F9 trial was selected as the best formulation. These results indicated that the selected formulation was stable during the test period of accelerated stability studies. The In-vitro drug release profile of the drugs was compared with marketed reference products of Tenofovir DF and Lamivudine. All the evaluated result was found to be satisfied with the reference products." @default.
- W2783982632 created "2018-01-26" @default.
- W2783982632 creator A5037701608 @default.
- W2783982632 date "2012-04-01" @default.
- W2783982632 modified "2023-09-26" @default.
- W2783982632 title "Formulation and Evaluation of Immediate Release Bilayer Tablets of Anti Retroviral Drugs" @default.
- W2783982632 hasPublicationYear "2012" @default.
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