FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783990112> ?p ?o ?g. }

• W2783990112 endingPage "100" @default.
• W2783990112 startingPage "88" @default.
• W2783990112 abstract "Trimethylamine-N-oxide (TMAO), gut microbiota-dependent metabolites, has been shown to be associated with cardiovascular diseases. However, little is known about the relationship between TMAO and vascular aging. Here, we observed a change in TMAO during the aging process and the effects of TMAO on vascular aging and endothelial cell (EC) senescence. We analyzed age-related plasma levels of TMAO in young adults (18–44 years old), older adults (≥ 65 years old), and 1-month-old, 3-month-old, 6-month-old and 10-month-old senescence-accelerated mouse prone 8 (SAMP8) and age-matched senescence-accelerated mouse resistance 1 (SAMR1) models. We found that circulating TMAO increased with age both in humans and mice. Next, we observed that a TMAO treatment for 16 weeks induced vascular aging in SAMR1 mice and accelerated the process in SAMP8 mice, as measured by an upregulation of senescence markers including senescence-associated β-galactosidase (SA-β-gal), p53, and p21, vascular dysfunction and remodeling. In vitro, we demonstrated that prolonged TMAO treatment induced senescence in human umbilical vein endothelial cells (HUVECs), characterized by reduced cell proliferation, increased expressions of senescence markers, stagnate G0/G1, and impaired cell migration. Furthermore, TMAO suppressed sirtuin 1 (SIRT1) expression and increased oxidative stress both in vivo and in vitro and then activated the p53/p21/Rb pathway resulting in increased p53, acetylation of p53, p21, and decreased CDK2, cyclinE1, and phosphorylation of Rb. In summary, these data suggest that elevated circulating TMAO during the aging process may deteriorate EC senescence and vascular aging, which is probably associated with repression of SIRT1 expression and increased oxidative stress, and, thus, the activation of the p53/p21/Rb pathway." @default.
• W2783990112 created "2018-01-26" @default.
• W2783990112 creator A5023476924 @default.
• W2783990112 creator A5030435405 @default.
• W2783990112 creator A5031231155 @default.
• W2783990112 creator A5046696643 @default.
• W2783990112 creator A5047357593 @default.
• W2783990112 creator A5050526843 @default.
• W2783990112 creator A5051608735 @default.
• W2783990112 creator A5052787818 @default.
• W2783990112 creator A5057117256 @default.
• W2783990112 creator A5070273499 @default.
• W2783990112 creator A5080017947 @default.
• W2783990112 date "2018-02-01" @default.
• W2783990112 modified "2023-10-16" @default.
• W2783990112 title "Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress" @default.
• W2783990112 cites W1550849850 @default.
• W2783990112 cites W1578616085 @default.
• W2783990112 cites W1881390540 @default.
• W2783990112 cites W1965021718 @default.
• W2783990112 cites W1969643223 @default.
• W2783990112 cites W1982481909 @default.
• W2783990112 cites W1983986440 @default.
• W2783990112 cites W1987000649 @default.
• W2783990112 cites W1991855600 @default.
• W2783990112 cites W1995188356 @default.
• W2783990112 cites W2012753961 @default.
• W2783990112 cites W2016019060 @default.
• W2783990112 cites W2027042725 @default.
• W2783990112 cites W2029423988 @default.
• W2783990112 cites W2039822562 @default.
• W2783990112 cites W2046971089 @default.
• W2783990112 cites W2104721620 @default.
• W2783990112 cites W2104908670 @default.
• W2783990112 cites W2108887402 @default.
• W2783990112 cites W2109588629 @default.
• W2783990112 cites W2115944543 @default.
• W2783990112 cites W2119343060 @default.
• W2783990112 cites W2123799914 @default.
• W2783990112 cites W2124561899 @default.
• W2783990112 cites W2142194547 @default.
• W2783990112 cites W2142942734 @default.
• W2783990112 cites W2149515881 @default.
• W2783990112 cites W2150350691 @default.
• W2783990112 cites W2153273912 @default.
• W2783990112 cites W2159245434 @default.
• W2783990112 cites W2159329277 @default.
• W2783990112 cites W2160802482 @default.
• W2783990112 cites W2170850325 @default.
• W2783990112 cites W2193792657 @default.
• W2783990112 cites W2257321757 @default.
• W2783990112 cites W2288501492 @default.
• W2783990112 cites W2304685302 @default.
• W2783990112 cites W2342504128 @default.
• W2783990112 cites W2343520201 @default.
• W2783990112 cites W2395207553 @default.
• W2783990112 cites W2406498263 @default.
• W2783990112 cites W2508485654 @default.
• W2783990112 cites W2530648884 @default.
• W2783990112 cites W2550560946 @default.
• W2783990112 cites W2583372114 @default.
• W2783990112 cites W2614365291 @default.
• W2783990112 cites W2617058021 @default.
• W2783990112 cites W2625290695 @default.
• W2783990112 cites W3015544325 @default.
• W2783990112 doi "https://doi.org/10.1016/j.freeradbiomed.2018.01.007" @default.
• W2783990112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29325896" @default.
• W2783990112 hasPublicationYear "2018" @default.
• W2783990112 type Work @default.
• W2783990112 sameAs 2783990112 @default.
• W2783990112 citedByCount "151" @default.
• W2783990112 countsByYear W27839901122018 @default.
• W2783990112 countsByYear W27839901122019 @default.
• W2783990112 countsByYear W27839901122020 @default.
• W2783990112 countsByYear W27839901122021 @default.
• W2783990112 countsByYear W27839901122022 @default.
• W2783990112 countsByYear W27839901122023 @default.
• W2783990112 crossrefType "journal-article" @default.
• W2783990112 hasAuthorship W2783990112A5023476924 @default.
• W2783990112 hasAuthorship W2783990112A5030435405 @default.
• W2783990112 hasAuthorship W2783990112A5031231155 @default.
• W2783990112 hasAuthorship W2783990112A5046696643 @default.
• W2783990112 hasAuthorship W2783990112A5047357593 @default.
• W2783990112 hasAuthorship W2783990112A5050526843 @default.
• W2783990112 hasAuthorship W2783990112A5051608735 @default.
• W2783990112 hasAuthorship W2783990112A5052787818 @default.
• W2783990112 hasAuthorship W2783990112A5057117256 @default.
• W2783990112 hasAuthorship W2783990112A5070273499 @default.
• W2783990112 hasAuthorship W2783990112A5080017947 @default.
• W2783990112 hasConcept C104317684 @default.
• W2783990112 hasConcept C126322002 @default.
• W2783990112 hasConcept C127561419 @default.
• W2783990112 hasConcept C134018914 @default.
• W2783990112 hasConcept C185592680 @default.
• W2783990112 hasConcept C2776149385 @default.
• W2783990112 hasConcept C2776151105 @default.
• W2783990112 hasConcept C2776536020 @default.
• W2783990112 hasConcept C2780924926 @default.

• next