Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783991255> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- W2783991255 endingPage "S142" @default.
- W2783991255 startingPage "S142" @default.
- W2783991255 abstract "Angiosarcoma of the spleen is an uncommon condition, comprising only 2.7% of all angiosarcomas. It is common for splenic angiosarcoma to metastasize to other organs. The diagnosis of splenic angiosarcoma is made by either acute abdominal symptoms after splenic rupture or incidentally from radiologic surveillance. We report herein a case of splenic angiosarcoma with documented unique genomic mutations that have not been previously reported. An 81-year-old man presented with thrombocytopenia and progressive splenomegaly over several years; a diagnosis of immune thrombocytopenia purpura was initially made. The patient subsequently developed sclerotic-blastic bone lesions with worsened splenomegaly. Bone marrow and bone biopsies revealed angiosarcoma, which was considered to be metastatic from the spleen based on imaging. He received multiple cycles of chemotherapy with minimal improvement. Eventually, the patient underwent splenectomy and the diagnosis of primary splenic angiosarcoma was made. Tissue sections showed a mitotically active cellular spindle cell neoplasm with pleomorphic nuclei, diffusely configured in anastomosing vasoformative channels. Zones of fibrosis, infarction, or active tumor necrosis comprised less than 5% of the splenic volume. Metastases to lymph nodes, peripancreatic fat and bone marrow were documented. Immunostains showed diffuse and strong immunoreactivity for CD31 and CD34, supporting a vascular origin. Molecular testing showed mutations in the following genes: ATRX, CDKN2A/B, EPHA3, MLL2, NOTCH2, and TET2. Primary splenic angiosarcoma is a rare entity with limited published molecular data. To our knowledge, the composite of genomic mutations outlined herein have not been previously reported in splenic angiosarcomas. CDKN2A/B has been reported in hepatic angiosarcomas." @default.
- W2783991255 created "2018-01-26" @default.
- W2783991255 creator A5002300356 @default.
- W2783991255 creator A5022525731 @default.
- W2783991255 creator A5043669779 @default.
- W2783991255 date "2018-01-01" @default.
- W2783991255 modified "2023-09-25" @default.
- W2783991255 title "329 Unique Genomic Alterations in a Case of Splenic Angiosarcoma" @default.
- W2783991255 doi "https://doi.org/10.1093/ajcp/aqx127.328" @default.
- W2783991255 hasPublicationYear "2018" @default.
- W2783991255 type Work @default.
- W2783991255 sameAs 2783991255 @default.
- W2783991255 citedByCount "0" @default.
- W2783991255 crossrefType "journal-article" @default.
- W2783991255 hasAuthorship W2783991255A5002300356 @default.
- W2783991255 hasAuthorship W2783991255A5022525731 @default.
- W2783991255 hasAuthorship W2783991255A5043669779 @default.
- W2783991255 hasBestOaLocation W27839912551 @default.
- W2783991255 hasConcept C126322002 @default.
- W2783991255 hasConcept C142724271 @default.
- W2783991255 hasConcept C2776309230 @default.
- W2783991255 hasConcept C2779217266 @default.
- W2783991255 hasConcept C2780007613 @default.
- W2783991255 hasConcept C2780931953 @default.
- W2783991255 hasConcept C2781082889 @default.
- W2783991255 hasConcept C71924100 @default.
- W2783991255 hasConceptScore W2783991255C126322002 @default.
- W2783991255 hasConceptScore W2783991255C142724271 @default.
- W2783991255 hasConceptScore W2783991255C2776309230 @default.
- W2783991255 hasConceptScore W2783991255C2779217266 @default.
- W2783991255 hasConceptScore W2783991255C2780007613 @default.
- W2783991255 hasConceptScore W2783991255C2780931953 @default.
- W2783991255 hasConceptScore W2783991255C2781082889 @default.
- W2783991255 hasConceptScore W2783991255C71924100 @default.
- W2783991255 hasIssue "suppl_1" @default.
- W2783991255 hasLocation W27839912551 @default.
- W2783991255 hasOpenAccess W2783991255 @default.
- W2783991255 hasPrimaryLocation W27839912551 @default.
- W2783991255 hasRelatedWork W1967799807 @default.
- W2783991255 hasRelatedWork W2010121768 @default.
- W2783991255 hasRelatedWork W2094538414 @default.
- W2783991255 hasRelatedWork W2357572431 @default.
- W2783991255 hasRelatedWork W2374648076 @default.
- W2783991255 hasRelatedWork W2754311688 @default.
- W2783991255 hasRelatedWork W3197759093 @default.
- W2783991255 hasRelatedWork W4290748209 @default.
- W2783991255 hasRelatedWork W4311031887 @default.
- W2783991255 hasRelatedWork W105738616 @default.
- W2783991255 hasVolume "149" @default.
- W2783991255 isParatext "false" @default.
- W2783991255 isRetracted "false" @default.
- W2783991255 magId "2783991255" @default.
- W2783991255 workType "article" @default.