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- W2783992342 abstract "Individual patient data (IPD) meta-analysis is considered to be a gold standard when the results of several randomized trials are combined. Recent initiatives on sharing IPD from clinical trials offer unprecedented opportunities for using such data in IPD meta-analyses. First, we discuss the evidence generated and the benefits obtained by a long-established prospective IPD meta-analysis in early breast cancer. Next, we discuss a data-sharing system that has been adopted by several pharmaceutical sponsors. We review a number of retrospective IPD meta-analyses that have already been proposed using this data-sharing system. Finally, we discuss the role of data sharing in IPD meta-analysis in the future. Treatment effects can be more reliably estimated in both types of IPD meta-analyses than with summary statistics extracted from published papers. Specifically, with rich covariate information available on each patient, prognostic and predictive factors can be identified or confirmed. Also, when several endpoints are available, surrogate endpoints can be assessed statistically. Although there are difficulties in conducting, analyzing, and interpreting retrospective IPD meta-analysis utilizing the currently available data-sharing systems, data sharing will play an important role in IPD meta-analysis in the future." @default.
- W2783992342 created "2018-01-26" @default.
- W2783992342 creator A5013344739 @default.
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- W2783992342 date "2018-01-12" @default.
- W2783992342 modified "2023-09-29" @default.
- W2783992342 title "Meta-analysis of randomized clinical trials in the era of individual patient data sharing" @default.
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- W2783992342 doi "https://doi.org/10.1007/s10147-018-1237-z" @default.
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