FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783993205> ?p ?o ?g. }

• W2783993205 endingPage "174480691775099" @default.
• W2783993205 startingPage "174480691775099" @default.
• W2783993205 abstract "Chemotherapy drugs such as oxaliplatin can increase nociceptive neuron excitability to result in neuropathic pain in orofacial and other regions in patients following chemotherapy. However, mechanisms underlying chemotherapy-induced increases of nociceptive neuron excitability are not fully understood. Kv4.3 channels are voltage-gated K+ channels mediating A-type K+ (IA) currents to control neuronal excitability. In the present study, we examined Kv4.3 channel expression on trigeminal neurons that innervate orofacial regions (V2 TG neurons) of rats using immunostaining method. We showed that strong Kv4.3 immunoreactivity (Kv4.3-ir) was present mainly in small-sized V2 TG neurons. The numbers of Kv4.3-ir positive V2 TG neurons were significantly reduced in oxaliplatin-treated rats, suggesting down-regulation of Kv4.3 channel expression on V2 TG neurons by the chemotherapy drug. Patch-clamp recordings from acutely dissociated rat V2 TG neurons showed that almost all nociceptive-like V2 TG neurons displayed IA currents with slow inactivation kinetics. The amplitudes of IA currents were significantly reduced in these nociceptive-like V2 TG neurons of oxaliplatin-treated group. Furthermore, we found that the excitability of nociceptive-like V2 TG neurons was significantly higher in the oxaliplatin-treated group than in the control group. These findings raise a possibility that down-regulation of Kv4.3 channels and IA currents in nociceptive V2 TG neurons is an underlying mechanism of oxaliplatin-induced orofacial neuropathic pain." @default.
• W2783993205 created "2018-01-26" @default.
• W2783993205 creator A5040415138 @default.
• W2783993205 creator A5041823704 @default.
• W2783993205 creator A5045266132 @default.
• W2783993205 date "2018-01-01" @default.
• W2783993205 modified "2023-10-06" @default.
• W2783993205 title "Down-regulation of Kv4.3 channels and a-type K⁺ currents in V2 trigeminal ganglion neurons of rats following oxaliplatin treatment" @default.
• W2783993205 cites W1557501339 @default.
• W2783993205 cites W1624886486 @default.
• W2783993205 cites W1982190221 @default.
• W2783993205 cites W2003237376 @default.
• W2783993205 cites W2009367742 @default.
• W2783993205 cites W2020077263 @default.
• W2783993205 cites W2024451662 @default.
• W2783993205 cites W2029345951 @default.
• W2783993205 cites W2032250203 @default.
• W2783993205 cites W2048374630 @default.
• W2783993205 cites W2049209075 @default.
• W2783993205 cites W2088110780 @default.
• W2783993205 cites W2091327625 @default.
• W2783993205 cites W2113154361 @default.
• W2783993205 cites W2138994529 @default.
• W2783993205 cites W2151785319 @default.
• W2783993205 cites W2159470318 @default.
• W2783993205 cites W2280099523 @default.
• W2783993205 cites W2416337138 @default.
• W2783993205 cites W2465050440 @default.
• W2783993205 cites W2541757731 @default.
• W2783993205 cites W2737459506 @default.
• W2783993205 doi "https://doi.org/10.1177/1744806917750995" @default.
• W2783993205 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5764133" @default.
• W2783993205 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29313436" @default.
• W2783993205 hasPublicationYear "2018" @default.
• W2783993205 type Work @default.
• W2783993205 sameAs 2783993205 @default.
• W2783993205 citedByCount "26" @default.
• W2783993205 countsByYear W27839932052018 @default.
• W2783993205 countsByYear W27839932052019 @default.
• W2783993205 countsByYear W27839932052020 @default.
• W2783993205 countsByYear W27839932052021 @default.
• W2783993205 countsByYear W27839932052022 @default.
• W2783993205 countsByYear W27839932052023 @default.
• W2783993205 crossrefType "journal-article" @default.
• W2783993205 hasAuthorship W2783993205A5040415138 @default.
• W2783993205 hasAuthorship W2783993205A5041823704 @default.
• W2783993205 hasAuthorship W2783993205A5045266132 @default.
• W2783993205 hasBestOaLocation W27839932051 @default.
• W2783993205 hasConcept C121608353 @default.
• W2783993205 hasConcept C126322002 @default.
• W2783993205 hasConcept C147944092 @default.
• W2783993205 hasConcept C15490471 @default.
• W2783993205 hasConcept C169760540 @default.
• W2783993205 hasConcept C170493617 @default.
• W2783993205 hasConcept C185263204 @default.
• W2783993205 hasConcept C185592680 @default.
• W2783993205 hasConcept C2776352249 @default.
• W2783993205 hasConcept C2777107010 @default.
• W2783993205 hasConcept C2778794669 @default.
• W2783993205 hasConcept C2780962732 @default.
• W2783993205 hasConcept C526805850 @default.
• W2783993205 hasConcept C71924100 @default.
• W2783993205 hasConcept C86803240 @default.
• W2783993205 hasConcept C94487597 @default.
• W2783993205 hasConcept C98274493 @default.
• W2783993205 hasConceptScore W2783993205C121608353 @default.
• W2783993205 hasConceptScore W2783993205C126322002 @default.
• W2783993205 hasConceptScore W2783993205C147944092 @default.
• W2783993205 hasConceptScore W2783993205C15490471 @default.
• W2783993205 hasConceptScore W2783993205C169760540 @default.
• W2783993205 hasConceptScore W2783993205C170493617 @default.
• W2783993205 hasConceptScore W2783993205C185263204 @default.
• W2783993205 hasConceptScore W2783993205C185592680 @default.
• W2783993205 hasConceptScore W2783993205C2776352249 @default.
• W2783993205 hasConceptScore W2783993205C2777107010 @default.
• W2783993205 hasConceptScore W2783993205C2778794669 @default.
• W2783993205 hasConceptScore W2783993205C2780962732 @default.
• W2783993205 hasConceptScore W2783993205C526805850 @default.
• W2783993205 hasConceptScore W2783993205C71924100 @default.
• W2783993205 hasConceptScore W2783993205C86803240 @default.
• W2783993205 hasConceptScore W2783993205C94487597 @default.
• W2783993205 hasConceptScore W2783993205C98274493 @default.
• W2783993205 hasFunder F4320337365 @default.
• W2783993205 hasLocation W27839932051 @default.
• W2783993205 hasLocation W27839932052 @default.
• W2783993205 hasLocation W27839932053 @default.
• W2783993205 hasLocation W27839932054 @default.
• W2783993205 hasOpenAccess W2783993205 @default.
• W2783993205 hasPrimaryLocation W27839932051 @default.
• W2783993205 hasRelatedWork W1965457201 @default.
• W2783993205 hasRelatedWork W2010972175 @default.
• W2783993205 hasRelatedWork W2055153848 @default.
• W2783993205 hasRelatedWork W2147909455 @default.
• W2783993205 hasRelatedWork W2290010080 @default.
• W2783993205 hasRelatedWork W2317048835 @default.
• W2783993205 hasRelatedWork W2479745712 @default.
• W2783993205 hasRelatedWork W2615427234 @default.
• W2783993205 hasRelatedWork W2789435038 @default.

• next