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- W2783993391 abstract "In general, we agree with the points raised by Drs. Ruisinger, Moriarty, and Backes, specifically that some formulations of coenzyme Q10 may be better absorbed than others and may thus have a clinically relevant effect in some patients with SAM. However, we wish to provide some additional context in rebuttal. The data regarding the reduced form of coenzyme Q10 (ubiquinol) having superior pharmacokinetic properties—specifically, a greater area under the concentration–time curve—compared with coenzyme Q10 (ubiquinone) were primarily derived from a study of 10 healthy volunteers.1 Furthermore, 1 of the sources cited by Dr. Ruisinger et al., the website for Ubiquinol.org, is hosted by a chemical manufacturing company that commercially produces co-enzyme Q10 supplements. We repeated a literature search that included ubiquinol and did not find additional studies relevant to our article. However, we agree that most reports do not explicitly state the form of coenzyme Q10 used and thus omit context vital to interpreting their results. The dosage of coenzyme Q10 ranged from 50 to 600 mg daily in the trials we cited, yet no dose–response effect could be identified among them; product and formulation variability may have confounded the interpretation of the studies’ results." @default.
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- W2783993391 date "2018-01-15" @default.
- W2783993391 modified "2023-10-18" @default.
- W2783993391 title "Coenzyme Q10 for statin-associated myalgia" @default.
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- W2783993391 doi "https://doi.org/10.2146/ajhp170680" @default.
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