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• W2783994401 abstract "Hepatitis B virus ( HBV ) X ( HB x) protein is a pivotal regulator of HBV ‐triggered autophagy. However, the role of HB x‐induced epigenetic changes in autophagy remains largely unknown. The cytoplasmic (Cyt) high‐mobility group box 1 ( HMGB 1) has been identified as a positive regulator of autophagy, and its Cyt translocation is closely associated with its acetylation status. Here, we evaluated the function of HMGB 1 in HB x‐mediated autophagy and its association with histone deacetylase ( HDAC ). Using cell lines with enforced expression of HB x, we demonstrated that HB x upregulated the expression of HMGB 1 and promoted its Cyt translocation by acetylation to facilitate autophagy. We further identified the underlying mechanism by which decreased nuclear HDAC activity and expression levels contribute to the HB x‐promoted hyperacetylation and subsequent translocation of HMGB 1. We also identified the HDAC 1 isoform as a critical factor in regulating this phenomenon. In addition, HB x bound to HMGB 1 in the cytoplasm, which triggered autophagy in hepatocytes. Pharmacological inhibition of HMGB 1 Cyt translocation with ethyl pyruvate prevented HB x‐induced autophagy. These results demonstrate a novel function of acetylated HMGB 1 in HB x‐mediated autophagy in hepatocytes." @default.
• W2783994401 created "2018-01-26" @default.
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• W2783994401 date "2018-01-24" @default.
• W2783994401 modified "2023-10-17" @default.
• W2783994401 title "Crosstalk between hepatitis B virus X and high-mobility group box 1 facilitates autophagy in hepatocytes" @default.
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• W2783994401 doi "https://doi.org/10.1002/1878-0261.12165" @default.
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• W2783994401 hasPublicationYear "2018" @default.
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