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- W2783994491 abstract "To obtain a desirable therapeutic response, the correct amount of the drug should betransported and delivered to the site of action. The distribution to other tissues therefore seems to be a potential cause for toxicity. Targeted drug delivery system involves a number of essential bio ligands for bio signalling and physiological cell need. They are operated through bio ports which are referred as receptors. The ligand-receptor interactions are highly stereo specific. Therefore ligands or receptors could be exploited for cell specific drug delivery. The polymer enhances the binding of glimepiride nanoparticles in specific or targeted site with sustained release of drug which increases the therapeutic efficacy. These nanoparticles may also reduce the dose and dose frequency with desired therapeutic response. The preformulation studies were performed using FTIR. The spectra pure drug and the formulation were examined. The study revealed the absence of interaction between drug and the polymer. All the batches of nanoparticles (CD1-CD10) were prepared by kneading method. Formulation was subjected to following evaluation tests which involves; Entrapment efficiency, In vitro drug release studies, Microscopic determination and Particle size determination the entrapment efficiency of the optimized formulation was 94±0.05% and the in vitro drug release was 94.89% after 24 hrs. It obeys zero order, follows diffusion and erosion mechanism of release. Particle size determination by SEM shows the best formulation containing size of 170 nm. Therefore it can target the tissues and has a quick onset of action. The optimized formulation was examined for zeta potential determination. The formulation CD10 showed maximum deviation of -4.65 mV which demonstrates that the particles are separate and highly repelling. The repelling property was more useful in decreasingopsonisation. Further studies are to be carried out to reduce the side effects. Therefore, formulated glimepiride nanoparticles can be expected to gain onsiderable attention in the treatment of type 2 diabetes mellitus due to its improved therapeutic activity." @default.
- W2783994491 created "2018-01-26" @default.
- W2783994491 creator A5013740367 @default.
- W2783994491 date "2014-04-01" @default.
- W2783994491 modified "2023-09-27" @default.
- W2783994491 title "Fabrication of Cyclodextrin Loaded Glimepiride Nanoparticles and Its Evaluation" @default.
- W2783994491 hasPublicationYear "2014" @default.
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