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- W2783996290 abstract "Abstract Background and objectives The risk of de novo donor‐specific antibody (dn DSA ) development following BK viremia ( BKV ) or nephropathy ( BKN ) after kidney transplant remains unclear. We aimed to evaluate the relationships among dn DSA , BKV ( BK blood PCR > 15 000 copies), BKN , antibody‐mediated rejection ( AMR ), and allograft loss. Patients and methods We performed a retrospective cohort study of 904 solitary kidney transplant recipients transplanted between 10/2007 and 5/2014. Cox proportional hazards regression with time‐dependent covariates were used to assess the relationships among BKN , isolated BKV , dn DSA , and the subsequent risk of AMR and allograft loss. Results In multivariate analysis, we observed that BKN , but not BKV was a risk factor for dn DSA ( HR , 3.18, P = .008). Of the patients with BK nephropathy, 14.0% (6/43) developed dn DSA , which occurred within 14 months of BK diagnosis. Dn DSA in this setting remains a risk factor for subsequent AMR ( HR 4.75, P = .0001) and allograft loss ( HR 2.63, P = .018). Conclusions BKN is an independent risk factor for development of dn DSA . Improved understanding of the characteristics of patients with BKN who are at highest risk for development of dn DSA would be valuable to customize immunosuppression reduction in this population." @default.
- W2783996290 created "2018-01-26" @default.
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- W2783996290 date "2018-02-11" @default.
- W2783996290 modified "2023-10-18" @default.
- W2783996290 title "De novo donor-specific antibody following BK nephropathy: The incidence and association with antibody-mediated rejection" @default.
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- W2783996290 doi "https://doi.org/10.1111/ctr.13194" @default.
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