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- W2783996559 abstract "The assembly of functional neuronal circuits requires growth cones to extend in defined directions and recognize the correct synaptic partners. Homophilic adhesion between vertebrate Sidekick proteins promotes synapse formation between retinal neurons involved in visual motion detection. We show here that that Drosophila Sidekick accumulates in specific synaptic layers of the developing motion detection circuit and is necessary for normal optomotor behavior. Sidekick is required in photoreceptors, but not their target lamina neurons, to promote the alignment of lamina neurons into columns and subsequent sorting of photoreceptor axons into synaptic modules based on their precise spatial orientation. Sidekick is also localized to the dendrites of the direction-selective T4 and T5 cells, and is expressed in some of their presynaptic partners. In contrast to its vertebrate homologues, Sidekick is not essential for T4 and T5 to direct their dendrites to the appropriate layers or to receive synaptic contacts. These results illustrate a conserved requirement for Sidekick proteins to establish visual motion detection circuits that is achieved through distinct cellular mechanisms in Drosophila and vertebrates." @default.
- W2783996559 created "2018-01-26" @default.
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- W2783996559 date "2018-01-01" @default.
- W2783996559 modified "2023-10-02" @default.
- W2783996559 title "<i>Drosophila</i>Sidekick is required in developing photoreceptors to enable visual motion detection" @default.
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- W2783996559 doi "https://doi.org/10.1242/dev.158246" @default.
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- W2783996559 hasPublicationYear "2018" @default.
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