Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783997718> ?p ?o ?g. }
- W2783997718 endingPage "238" @default.
- W2783997718 startingPage "224" @default.
- W2783997718 abstract "The Apolipoprotein B mRNA editing complex (APOBEC) family of enzymes contains single-stranded polynucleotide cytidine deaminases. These enzymes catalyze the deamination of cytidine in RNA or single-stranded DNA, which forms uracil. From this 11 member enzyme family in humans, the deamination of single-stranded DNA by the seven APOBEC3 family members is considered here. The APOBEC3 family has many roles, such as restricting endogenous and exogenous retrovirus replication and retrotransposon insertion events and reducing DNA-induced inflammation. Similar to other APOBEC family members, the APOBEC3 enzymes are a double-edged sword that can catalyze deamination of cytosine in genomic DNA, which results in potential genomic instability due to the many mutagenic fates of uracil in DNA. Here, we discuss how these enzymes find their single-stranded DNA substrate in different biological contexts such as during human immunodeficiency virus (HIV) proviral DNA synthesis, retrotransposition of the LINE-1 element, and the “off-target” genomic DNA substrate. The enzymes must be able to efficiently deaminate transiently available single-stranded DNA during reverse transcription, replication, or transcription. Specific biochemical characteristics promote deamination in each situation to increase enzyme efficiency through processivity, rapid enzyme cycling between substrates, or oligomerization state. The use of biochemical data to clarify biological functions and alignment with cellular data is discussed. Models to bridge knowledge from biochemical, structural, and single molecule experiments are presented." @default.
- W2783997718 created "2018-01-26" @default.
- W2783997718 creator A5019575748 @default.
- W2783997718 creator A5062062407 @default.
- W2783997718 creator A5073473183 @default.
- W2783997718 date "2018-01-18" @default.
- W2783997718 modified "2023-09-23" @default.
- W2783997718 title "Biochemical Basis of APOBEC3 Deoxycytidine Deaminase Activity on Diverse DNA Substrates" @default.
- W2783997718 cites W1464437310 @default.
- W2783997718 cites W1842792112 @default.
- W2783997718 cites W1907408825 @default.
- W2783997718 cites W1964549900 @default.
- W2783997718 cites W1965292045 @default.
- W2783997718 cites W1966251372 @default.
- W2783997718 cites W1966343819 @default.
- W2783997718 cites W1967244446 @default.
- W2783997718 cites W1967484841 @default.
- W2783997718 cites W1969475895 @default.
- W2783997718 cites W1969593814 @default.
- W2783997718 cites W1971770597 @default.
- W2783997718 cites W1975784563 @default.
- W2783997718 cites W1976145850 @default.
- W2783997718 cites W1977239712 @default.
- W2783997718 cites W1978624231 @default.
- W2783997718 cites W1978744896 @default.
- W2783997718 cites W1979946545 @default.
- W2783997718 cites W1981333260 @default.
- W2783997718 cites W1982475481 @default.
- W2783997718 cites W1984236815 @default.
- W2783997718 cites W1988383488 @default.
- W2783997718 cites W1995598331 @default.
- W2783997718 cites W1997555001 @default.
- W2783997718 cites W1998639433 @default.
- W2783997718 cites W1998993816 @default.
- W2783997718 cites W2001375348 @default.
- W2783997718 cites W2003108516 @default.
- W2783997718 cites W2003665515 @default.
- W2783997718 cites W2007861318 @default.
- W2783997718 cites W2008684414 @default.
- W2783997718 cites W2010268348 @default.
- W2783997718 cites W2012564250 @default.
- W2783997718 cites W2014067586 @default.
- W2783997718 cites W2015281347 @default.
- W2783997718 cites W2015820342 @default.
- W2783997718 cites W2020911697 @default.
- W2783997718 cites W2023035407 @default.
- W2783997718 cites W2023326716 @default.
- W2783997718 cites W2025363465 @default.
- W2783997718 cites W2027613370 @default.
- W2783997718 cites W2029782984 @default.
- W2783997718 cites W2032471242 @default.
- W2783997718 cites W2040222685 @default.
- W2783997718 cites W2040727563 @default.
- W2783997718 cites W2042486230 @default.
- W2783997718 cites W2043613093 @default.
- W2783997718 cites W2054437592 @default.
- W2783997718 cites W2056832684 @default.
- W2783997718 cites W2056834613 @default.
- W2783997718 cites W2060168918 @default.
- W2783997718 cites W2067211077 @default.
- W2783997718 cites W2069676221 @default.
- W2783997718 cites W2069752975 @default.
- W2783997718 cites W2070591584 @default.
- W2783997718 cites W2072816807 @default.
- W2783997718 cites W2073907008 @default.
- W2783997718 cites W2075049040 @default.
- W2783997718 cites W2076582857 @default.
- W2783997718 cites W2076626746 @default.
- W2783997718 cites W2077032210 @default.
- W2783997718 cites W2079513857 @default.
- W2783997718 cites W2083158919 @default.
- W2783997718 cites W2083358713 @default.
- W2783997718 cites W2084385617 @default.
- W2783997718 cites W2086429266 @default.
- W2783997718 cites W2090460944 @default.
- W2783997718 cites W2090697236 @default.
- W2783997718 cites W2092525424 @default.
- W2783997718 cites W2093311075 @default.
- W2783997718 cites W2096783891 @default.
- W2783997718 cites W2097653439 @default.
- W2783997718 cites W2098309323 @default.
- W2783997718 cites W2101836667 @default.
- W2783997718 cites W2102089867 @default.
- W2783997718 cites W2104153021 @default.
- W2783997718 cites W2110692613 @default.
- W2783997718 cites W2111079470 @default.
- W2783997718 cites W2113935510 @default.
- W2783997718 cites W2115819181 @default.
- W2783997718 cites W2118393957 @default.
- W2783997718 cites W2121647638 @default.
- W2783997718 cites W2122883276 @default.
- W2783997718 cites W2123805590 @default.
- W2783997718 cites W2124471061 @default.
- W2783997718 cites W2127713363 @default.
- W2783997718 cites W2131793664 @default.
- W2783997718 cites W2132373198 @default.
- W2783997718 cites W2135663451 @default.
- W2783997718 cites W2136716105 @default.