FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783997753> ?p ?o ?g. }

• W2783997753 endingPage "833" @default.
• W2783997753 startingPage "825" @default.
• W2783997753 abstract "The aim of the present study was to investigate the protective effects and underlying mechanisms of Garcinia xanthochymus, a perennial medicinal plant native to Yunnan, China, against H2O2-induced oxidative damage in rat pheochromacytoma PC12 cells. Preincubation of PC12 cells with fruit EtOAc fraction (fruit-EFr., 12.5–50 µmol·L−1) of G. xanthochymus for 24 h prior to H2O2 exposure markedly improved cell viability and increased the activities of antioxidant enzymes (superoxide dismutase, catalase, and heme oxygenase-1 [HO-1]), prevented lactate dehydrogenase release and lipid peroxidation malondialdehyde production, attenuated the decrease of matrix metalloproteinases (MMP), and scavenged reactive oxygen species (ROS). Fruit-EFr. also reduced BAX and cytochrome C expression and improved BCL-2 expression, thereby decreasing the ratio of BAX to BCL-2. Fruit-EFr. activated the nuclear translocation of NRF2 to increase HO-1 and induced the phosphorylation of AKT. Its cytoprotective effect was abolished by LY294002, a specific inhibitor of PI3K. Taken together, the above findings suggested that fruit-EFr.of G. xanthochymus could enhance cellular antioxidant defense capacity, at least in part, through upregulating HO-1 expression and activating the PI3K/AKT pathway and that it could suppress H2O2-induced oxidative damage via PI3K/AKT and NRF2/HO-1 signaling pathways." @default.
• W2783997753 created "2018-01-26" @default.
• W2783997753 creator A5005239588 @default.
• W2783997753 creator A5009426777 @default.
• W2783997753 creator A5027835055 @default.
• W2783997753 creator A5035778127 @default.
• W2783997753 creator A5052676364 @default.
• W2783997753 creator A5058338422 @default.
• W2783997753 creator A5071571332 @default.
• W2783997753 date "2017-11-01" @default.
• W2783997753 modified "2023-10-01" @default.
• W2783997753 title "Garcinia xanthochymus extract protects PC12 cells from H 2 O 2 -induced apoptosis through modulation of PI3K/AKT and NRF2/HO-1 pathways" @default.
• W2783997753 cites W1480863120 @default.
• W2783997753 cites W1936380547 @default.
• W2783997753 cites W1965093955 @default.
• W2783997753 cites W1981796480 @default.
• W2783997753 cites W1987220529 @default.
• W2783997753 cites W1996370639 @default.
• W2783997753 cites W1998788702 @default.
• W2783997753 cites W2000126595 @default.
• W2783997753 cites W2002726264 @default.
• W2783997753 cites W2006594341 @default.
• W2783997753 cites W2010740759 @default.
• W2783997753 cites W2013021190 @default.
• W2783997753 cites W2020445365 @default.
• W2783997753 cites W2026785870 @default.
• W2783997753 cites W2027597347 @default.
• W2783997753 cites W2057129789 @default.
• W2783997753 cites W2064095539 @default.
• W2783997753 cites W2065190343 @default.
• W2783997753 cites W2065572121 @default.
• W2783997753 cites W2069859786 @default.
• W2783997753 cites W2078583104 @default.
• W2783997753 cites W2081798195 @default.
• W2783997753 cites W2082137621 @default.
• W2783997753 cites W2087311397 @default.
• W2783997753 cites W2089518139 @default.
• W2783997753 cites W2104194752 @default.
• W2783997753 cites W2108700166 @default.
• W2783997753 cites W2114918609 @default.
• W2783997753 cites W2130879335 @default.
• W2783997753 cites W2134111206 @default.
• W2783997753 cites W2137078437 @default.
• W2783997753 cites W2164047955 @default.
• W2783997753 cites W2165201727 @default.
• W2783997753 cites W2168537582 @default.
• W2783997753 cites W2169878907 @default.
• W2783997753 cites W2170036297 @default.
• W2783997753 cites W2170942810 @default.
• W2783997753 cites W2307662827 @default.
• W2783997753 cites W2371050741 @default.
• W2783997753 doi "https://doi.org/10.1016/s1875-5364(18)30016-5" @default.
• W2783997753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29329609" @default.
• W2783997753 hasPublicationYear "2017" @default.
• W2783997753 type Work @default.
• W2783997753 sameAs 2783997753 @default.
• W2783997753 citedByCount "7" @default.
• W2783997753 countsByYear W27839977532019 @default.
• W2783997753 countsByYear W27839977532021 @default.
• W2783997753 countsByYear W27839977532022 @default.
• W2783997753 countsByYear W27839977532023 @default.
• W2783997753 crossrefType "journal-article" @default.
• W2783997753 hasAuthorship W2783997753A5005239588 @default.
• W2783997753 hasAuthorship W2783997753A5009426777 @default.
• W2783997753 hasAuthorship W2783997753A5027835055 @default.
• W2783997753 hasAuthorship W2783997753A5035778127 @default.
• W2783997753 hasAuthorship W2783997753A5052676364 @default.
• W2783997753 hasAuthorship W2783997753A5058338422 @default.
• W2783997753 hasAuthorship W2783997753A5071571332 @default.
• W2783997753 hasConcept C181199279 @default.
• W2783997753 hasConcept C185592680 @default.
• W2783997753 hasConcept C190283241 @default.
• W2783997753 hasConcept C2775838275 @default.
• W2783997753 hasConcept C2776151105 @default.
• W2783997753 hasConcept C2776217839 @default.
• W2783997753 hasConcept C2776912716 @default.
• W2783997753 hasConcept C2778401633 @default.
• W2783997753 hasConcept C2778979269 @default.
• W2783997753 hasConcept C2779219270 @default.
• W2783997753 hasConcept C2780829032 @default.
• W2783997753 hasConcept C48349386 @default.
• W2783997753 hasConcept C55493867 @default.
• W2783997753 hasConcept C75217442 @default.
• W2783997753 hasConcept C86554907 @default.
• W2783997753 hasConcept C86803240 @default.
• W2783997753 hasConcept C98274493 @default.
• W2783997753 hasConceptScore W2783997753C181199279 @default.
• W2783997753 hasConceptScore W2783997753C185592680 @default.
• W2783997753 hasConceptScore W2783997753C190283241 @default.
• W2783997753 hasConceptScore W2783997753C2775838275 @default.
• W2783997753 hasConceptScore W2783997753C2776151105 @default.
• W2783997753 hasConceptScore W2783997753C2776217839 @default.
• W2783997753 hasConceptScore W2783997753C2776912716 @default.
• W2783997753 hasConceptScore W2783997753C2778401633 @default.
• W2783997753 hasConceptScore W2783997753C2778979269 @default.
• W2783997753 hasConceptScore W2783997753C2779219270 @default.
• W2783997753 hasConceptScore W2783997753C2780829032 @default.
• W2783997753 hasConceptScore W2783997753C48349386 @default.

• next