FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2784037295> ?p ?o ?g. }

• W2784037295 endingPage "346" @default.
• W2784037295 startingPage "342" @default.
• W2784037295 abstract "The cells of multicellular organisms receive extracellular signals using surface receptors. The extracellular domains (ECDs) of cell surface receptors function as interaction platforms, and as regulatory modules of receptor activation. Understanding how interactions between ECDs produce signal-competent receptor complexes is challenging because of their low biochemical tractability. In plants, the discovery of ECD interactions is complicated by the massive expansion of receptor families, which creates tremendous potential for changeover in receptor interactions. The largest of these families in Arabidopsis thaliana consists of 225 evolutionarily related leucine-rich repeat receptor kinases (LRR-RKs), which function in the sensing of microorganisms, cell expansion, stomata development and stem-cell maintenance. Although the principles that govern LRR-RK signalling activation are emerging, the systems-level organization of this family of proteins is unknown. Here, to address this, we investigated 40,000 potential ECD interactions using a sensitized high-throughput interaction assay, and produced an LRR-based cell surface interaction network (CSILRR) that consists of 567 interactions. To demonstrate the power of CSILRR for detecting biologically relevant interactions, we predicted and validated the functions of uncharacterized LRR-RKs in plant growth and immunity. In addition, we show that CSILRR operates as a unified regulatory network in which the LRR-RKs most crucial for its overall structure are required to prevent the aberrant signalling of receptors that are several network-steps away. Thus, plants have evolved LRR-RK networks to process extracellular signals into carefully balanced responses." @default.
• W2784037295 created "2018-01-26" @default.
• W2784037295 creator A5004840481 @default.
• W2784037295 creator A5006208952 @default.
• W2784037295 creator A5010037856 @default.
• W2784037295 creator A5010043443 @default.
• W2784037295 creator A5020730213 @default.
• W2784037295 creator A5025817756 @default.
• W2784037295 creator A5032512329 @default.
• W2784037295 creator A5033042169 @default.
• W2784037295 creator A5036380907 @default.
• W2784037295 creator A5043054127 @default.
• W2784037295 creator A5046107174 @default.
• W2784037295 creator A5053499702 @default.
• W2784037295 creator A5054116469 @default.
• W2784037295 creator A5055236444 @default.
• W2784037295 creator A5060683911 @default.
• W2784037295 creator A5081315144 @default.
• W2784037295 creator A5082151650 @default.
• W2784037295 creator A5084003676 @default.
• W2784037295 creator A5085683971 @default.
• W2784037295 creator A5089335497 @default.
• W2784037295 creator A5089343278 @default.
• W2784037295 creator A5090460944 @default.
• W2784037295 date "2018-01-10" @default.
• W2784037295 modified "2023-10-14" @default.
• W2784037295 title "An extracellular network of Arabidopsis leucine-rich repeat receptor kinases" @default.
• W2784037295 cites W1858966548 @default.
• W2784037295 cites W1966128755 @default.
• W2784037295 cites W1967014654 @default.
• W2784037295 cites W1971164173 @default.
• W2784037295 cites W1975906637 @default.
• W2784037295 cites W1978840865 @default.
• W2784037295 cites W1980064967 @default.
• W2784037295 cites W1985910349 @default.
• W2784037295 cites W1996085478 @default.
• W2784037295 cites W1997054375 @default.
• W2784037295 cites W1998198773 @default.
• W2784037295 cites W1999600272 @default.
• W2784037295 cites W2028190290 @default.
• W2784037295 cites W2029835563 @default.
• W2784037295 cites W2033732626 @default.
• W2784037295 cites W2033983786 @default.
• W2784037295 cites W2060387060 @default.
• W2784037295 cites W2068165399 @default.
• W2784037295 cites W2077276598 @default.
• W2784037295 cites W2078385341 @default.
• W2784037295 cites W2097449851 @default.
• W2784037295 cites W2098115340 @default.
• W2784037295 cites W2104408271 @default.
• W2784037295 cites W2122955107 @default.
• W2784037295 cites W2123264056 @default.
• W2784037295 cites W2135057380 @default.
• W2784037295 cites W2136211508 @default.
• W2784037295 cites W2143406588 @default.
• W2784037295 cites W2144145301 @default.
• W2784037295 cites W2146256775 @default.
• W2784037295 cites W2148941537 @default.
• W2784037295 cites W2149148688 @default.
• W2784037295 cites W2152553184 @default.
• W2784037295 cites W2162424885 @default.
• W2784037295 cites W2170636855 @default.
• W2784037295 cites W2176839968 @default.
• W2784037295 cites W2251273271 @default.
• W2784037295 cites W2265181296 @default.
• W2784037295 cites W2272348825 @default.
• W2784037295 cites W2315721191 @default.
• W2784037295 cites W2326508739 @default.
• W2784037295 cites W2346787980 @default.
• W2784037295 cites W2462790555 @default.
• W2784037295 cites W2468020455 @default.
• W2784037295 cites W2479540212 @default.
• W2784037295 cites W2505457969 @default.
• W2784037295 cites W2511797710 @default.
• W2784037295 cites W2520458266 @default.
• W2784037295 cites W2531638358 @default.
• W2784037295 cites W2556869668 @default.
• W2784037295 cites W2588571662 @default.
• W2784037295 cites W2596886293 @default.
• W2784037295 cites W2599341269 @default.
• W2784037295 cites W2621877256 @default.
• W2784037295 cites W2761348969 @default.
• W2784037295 doi "https://doi.org/10.1038/nature25184" @default.
• W2784037295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6485605" @default.
• W2784037295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29320478" @default.
• W2784037295 hasPublicationYear "2018" @default.
• W2784037295 type Work @default.
• W2784037295 sameAs 2784037295 @default.
• W2784037295 citedByCount "210" @default.
• W2784037295 countsByYear W27840372952016 @default.
• W2784037295 countsByYear W27840372952018 @default.
• W2784037295 countsByYear W27840372952019 @default.
• W2784037295 countsByYear W27840372952020 @default.
• W2784037295 countsByYear W27840372952021 @default.
• W2784037295 countsByYear W27840372952022 @default.
• W2784037295 countsByYear W27840372952023 @default.
• W2784037295 crossrefType "journal-article" @default.
• W2784037295 hasAuthorship W2784037295A5004840481 @default.

• next