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- W2784069500 abstract "In the present work an attempt has been made to formulate and evaluate the transdermalpatches of repaglinide using various blends of polymer.The polymeric combinations EC/PVP and EC/HPMC used for the formulation oftransdermal patches showed good film forming property.The patches formed were thin, flexible, smooth and transparent.The weight variation tests showed less variation in weight and suggesting uniformdistribution of drug and polymer over the mercury surface.The thicknesses of the transdermal patches were found to increase on increasingconcentration of hydrophilic polymers like PVP and HPMC.All the patches showed good flexibility and folding endurance properties. The resultsuggests that the formulations with increased hydrophilic polymer concentration showedlong folding endurance.The moisture content in the patches were found to be low and formulations with morehydrophilic polymer concentrations showed more percentage moisture content.The drug content analysis showed minimum variations suggesting uniform distributionof drug.The in-vitro drug release studies showed that formulations EPA3, EPB3, EPC3, EHA3,EHB3 and EHC3 with increased concentration of hydrophilic polymer showed rapidrelease. Formulations EPC1 and EHC1 showed sustained release.The in-vitro permeation studies showed that the required target flux is achieved withformulations EPC1 and EHC1 which also produces a sustained release of the drug.Surface morphological studies by SEM showed the patch showed uniform smoothsurface and did not loose integrity after release.The results of compatibility studies by FTIR showed no interaction between the drug andpolymers.The result of stability studies no change in the physical appearance and drug contentsuggesting that the formulations remained stable during storage.It is concluded that solvent casting method using mercury substrate is useful forsuccessful development of matrix type transdermal patches. The sustained release of drugfrom the transdermal patches suggests that the frequency of administration may bereduced. Further, the transdermal patches may improve the bioavailability of the drug byavoiding hepatic first pass metabolism.Hence we can conclude that the polymer matrix provide sustained delivery ofdrug and these systems can be used to deliver drugs with short half life and lowtherapeutic index through transdermal drug delivery systems." @default.
- W2784069500 created "2018-01-26" @default.
- W2784069500 creator A5044669875 @default.
- W2784069500 date "2010-03-01" @default.
- W2784069500 modified "2023-09-27" @default.
- W2784069500 title "Design and Characterization of Transdermal Delivery of Repaglinide" @default.
- W2784069500 hasPublicationYear "2010" @default.
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