FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2784132020> ?p ?o ?g. }

• W2784132020 abstract "Abstract Chronic inflammatory and neuropathic pains are major public health concerns. Potential therapeutic targets include the ATP-gated purinergic receptors (P2RX) that contribute to these pathological types of pain in several different cell types. The purinergic receptors P2RX2 and P2RX3 are expressed by a specific subset of dorsal root ganglion neurons and directly shape pain processing by primary afferents. In contrast the P2RX4 and P2RX7 are mostly expressed in myeloid cells, where activation of these receptors triggers the release of various pro-inflammatory molecules. Here, we demonstrate that P2RX4 also controls calcium influx in mouse dorsal root ganglion neurons. P2RX4 is up-regulated in pain-processing neurons during long lasting peripheral inflammation and it co-localizes with Brain-Derived Neurotrophic Factor (BDNF). In the dorsal horn of the spinal cord, BDNF-dependent signaling pathways, phosphorylation of Erk1/2 and of the GluN1 subunit as well as the down regulation of the co-transporter KCC2, which are triggered by peripheral inflammation are impaired in P2RX4-deficient mice. Our results suggest that P2RX4, expressed by sensory neurons, controls neuronal BDNF release that contributes to hyper-excitability during chronic inflammatory pain and establish P2RX4 in sensory neurons as a new potential therapeutic target to treat hyperexcitability during chronic inflammatory pain." @default.
• W2784132020 created "2018-01-26" @default.
• W2784132020 creator A5002304291 @default.
• W2784132020 creator A5008279681 @default.
• W2784132020 creator A5038917899 @default.
• W2784132020 creator A5043306647 @default.
• W2784132020 creator A5058480540 @default.
• W2784132020 creator A5088162059 @default.
• W2784132020 date "2018-01-17" @default.
• W2784132020 modified "2023-09-27" @default.
• W2784132020 title "Sensory neuronal P2RX4 receptors controls BDNF signaling in inflammatory pain" @default.
• W2784132020 cites W1490568823 @default.
• W2784132020 cites W1568010017 @default.
• W2784132020 cites W1570703400 @default.
• W2784132020 cites W1675050582 @default.
• W2784132020 cites W1714184251 @default.
• W2784132020 cites W1762338891 @default.
• W2784132020 cites W1775244163 @default.
• W2784132020 cites W1942784841 @default.
• W2784132020 cites W1978269241 @default.
• W2784132020 cites W1984025105 @default.
• W2784132020 cites W2000720249 @default.
• W2784132020 cites W2004017460 @default.
• W2784132020 cites W2013186124 @default.
• W2784132020 cites W2025150024 @default.
• W2784132020 cites W2027236524 @default.
• W2784132020 cites W2031183261 @default.
• W2784132020 cites W2033072655 @default.
• W2784132020 cites W2033948582 @default.
• W2784132020 cites W2038381968 @default.
• W2784132020 cites W2042847144 @default.
• W2784132020 cites W2043946280 @default.
• W2784132020 cites W2054643756 @default.
• W2784132020 cites W2056148352 @default.
• W2784132020 cites W2081180556 @default.
• W2784132020 cites W2083489519 @default.
• W2784132020 cites W2087424227 @default.
• W2784132020 cites W2089588032 @default.
• W2784132020 cites W2091428840 @default.
• W2784132020 cites W2092666915 @default.
• W2784132020 cites W2096500024 @default.
• W2784132020 cites W2096539044 @default.
• W2784132020 cites W2109138542 @default.
• W2784132020 cites W2113138572 @default.
• W2784132020 cites W2113569836 @default.
• W2784132020 cites W2125831853 @default.
• W2784132020 cites W2126416149 @default.
• W2784132020 cites W2127635025 @default.
• W2784132020 cites W2128676313 @default.
• W2784132020 cites W2128994172 @default.
• W2784132020 cites W2144195410 @default.
• W2784132020 cites W2149622001 @default.
• W2784132020 cites W2170576851 @default.
• W2784132020 cites W2196308323 @default.
• W2784132020 cites W2201999685 @default.
• W2784132020 cites W2395959860 @default.
• W2784132020 cites W2513150856 @default.
• W2784132020 doi "https://doi.org/10.1038/s41598-018-19301-5" @default.
• W2784132020 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5772667" @default.
• W2784132020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29343707" @default.
• W2784132020 hasPublicationYear "2018" @default.
• W2784132020 type Work @default.
• W2784132020 sameAs 2784132020 @default.
• W2784132020 citedByCount "48" @default.
• W2784132020 countsByYear W27841320202018 @default.
• W2784132020 countsByYear W27841320202019 @default.
• W2784132020 countsByYear W27841320202020 @default.
• W2784132020 countsByYear W27841320202021 @default.
• W2784132020 countsByYear W27841320202022 @default.
• W2784132020 countsByYear W27841320202023 @default.
• W2784132020 crossrefType "journal-article" @default.
• W2784132020 hasAuthorship W2784132020A5002304291 @default.
• W2784132020 hasAuthorship W2784132020A5008279681 @default.
• W2784132020 hasAuthorship W2784132020A5038917899 @default.
• W2784132020 hasAuthorship W2784132020A5043306647 @default.
• W2784132020 hasAuthorship W2784132020A5058480540 @default.
• W2784132020 hasAuthorship W2784132020A5088162059 @default.
• W2784132020 hasBestOaLocation W27841320201 @default.
• W2784132020 hasConcept C126322002 @default.
• W2784132020 hasConcept C160539049 @default.
• W2784132020 hasConcept C169760540 @default.
• W2784132020 hasConcept C170493617 @default.
• W2784132020 hasConcept C172590197 @default.
• W2784132020 hasConcept C2776281502 @default.
• W2784132020 hasConcept C2776914184 @default.
• W2784132020 hasConcept C2777107010 @default.
• W2784132020 hasConcept C2778790584 @default.
• W2784132020 hasConcept C2778938600 @default.
• W2784132020 hasConcept C2779830541 @default.
• W2784132020 hasConcept C2780775167 @default.
• W2784132020 hasConcept C2781118164 @default.
• W2784132020 hasConcept C57306754 @default.
• W2784132020 hasConcept C67907053 @default.
• W2784132020 hasConcept C71924100 @default.
• W2784132020 hasConcept C86803240 @default.
• W2784132020 hasConceptScore W2784132020C126322002 @default.
• W2784132020 hasConceptScore W2784132020C160539049 @default.
• W2784132020 hasConceptScore W2784132020C169760540 @default.
• W2784132020 hasConceptScore W2784132020C170493617 @default.
• W2784132020 hasConceptScore W2784132020C172590197 @default.

• next