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- W2784152079 abstract "The study of this work was to use a swellablepolymer chosen among superdisintegrants, for improving the dissolutionrate of a sparingly soluble drug, loaded on its surface. Nifedipine, whichhas very low water solubility, was chosen as a model drug, while crosslinked sodium carboxymethyl cellulose (Ac-Di-Sol) was chosen as theswellable polymer. The Nifedipine /Ac-Di-Sol systems were prepared usingtwo different techniques: evaporation and spraying; in some preparationspolyethylene glycol (PEG 1500), sucrose palmitate (Sucrodent), or dioctylsodium sulfosuccinate (Aerosal OT) were added. The results of thedissolution tests showed that the dissolution rate of Nifedipine from thesystems prepared increase, particularly in the case of the preparationcomposed of Ac-Di-Sol plus surfactant agents. Attempts were made to increase the rate of drug release(disintegration) to enhance the in vitro dissolution of the poorlysoluble drug Etodolac by using extra, intra and partly intra andextra granular method of addition of sodium starch glycolate andcrospovidone as superdisintegrants and to develop a stableimmediate release formulation by wet granulation method." @default.
- W2784152079 created "2018-01-26" @default.
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- W2784152079 date "2009-03-01" @default.
- W2784152079 modified "2023-09-27" @default.
- W2784152079 title "Formulation and Evaluation of Etodolac Immediate Release Tablets by Using Superdisintegrants and Its Stability Studies" @default.
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- W2784152079 hasPublicationYear "2009" @default.
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