Matches in SemOpenAlex for { <https://semopenalex.org/work/W2784161566> ?p ?o ?g. }
- W2784161566 abstract "Gastrointestinal bacterial infection represents a significant threat to human health, as well as a burden on food animal production and welfare. Although there is advanced knowledge about the molecular mechanisms underlying pathogenesis, including the development of immune responses to these pathogens, gaps in knowledge persist. It is well established that gastrointestinal bacterial pathogens produce a myriad of proteins that affect the development and effectiveness of innate immune responses. However, relatively few proteins that directly affect lymphocytes responsible for humoral or cell-mediated immunity and memory have been identified. Here, we review factors produced by gastrointestinal bacterial pathogens that have direct T cell interactions and what is known about their functions and mechanisms of action. T cell-interacting bacterial proteins that have been identified to date mainly target three major T cell responses: activation and expansion, chemotaxis, or apoptosis. Further, the requirement for more focused studies to identify and understand additional mechanisms used by bacteria to directly affect the T cell immune response and how these may contribute to pathogenesis is highlighted. Increased knowledge in this area will help to drive development of better interventions in prevention and treatment of gastrointestinal bacterial infection." @default.
- W2784161566 created "2018-01-26" @default.
- W2784161566 creator A5003472139 @default.
- W2784161566 creator A5016868088 @default.
- W2784161566 creator A5024372488 @default.
- W2784161566 date "2018-05-01" @default.
- W2784161566 modified "2023-09-24" @default.
- W2784161566 title "Direct Manipulation of T Lymphocytes by Proteins of Gastrointestinal Bacterial Pathogens" @default.
- W2784161566 cites W1546822460 @default.
- W2784161566 cites W1558456773 @default.
- W2784161566 cites W1586370436 @default.
- W2784161566 cites W1621166403 @default.
- W2784161566 cites W1658131282 @default.
- W2784161566 cites W1717525481 @default.
- W2784161566 cites W1819784342 @default.
- W2784161566 cites W1888120829 @default.
- W2784161566 cites W1919359848 @default.
- W2784161566 cites W1946149151 @default.
- W2784161566 cites W1952296049 @default.
- W2784161566 cites W1959421699 @default.
- W2784161566 cites W1966591261 @default.
- W2784161566 cites W1970028645 @default.
- W2784161566 cites W1982110424 @default.
- W2784161566 cites W1983206455 @default.
- W2784161566 cites W1991245510 @default.
- W2784161566 cites W1992673079 @default.
- W2784161566 cites W1995707731 @default.
- W2784161566 cites W1999687660 @default.
- W2784161566 cites W2005305957 @default.
- W2784161566 cites W2005848280 @default.
- W2784161566 cites W2010340325 @default.
- W2784161566 cites W2010746515 @default.
- W2784161566 cites W2024929819 @default.
- W2784161566 cites W2043187565 @default.
- W2784161566 cites W2043431269 @default.
- W2784161566 cites W2044320282 @default.
- W2784161566 cites W2050702185 @default.
- W2784161566 cites W2052875067 @default.
- W2784161566 cites W2056047014 @default.
- W2784161566 cites W2059371737 @default.
- W2784161566 cites W2071743575 @default.
- W2784161566 cites W2073311659 @default.
- W2784161566 cites W2076673615 @default.
- W2784161566 cites W2079200908 @default.
- W2784161566 cites W2087464602 @default.
- W2784161566 cites W2105697998 @default.
- W2784161566 cites W2108650847 @default.
- W2784161566 cites W2109021251 @default.
- W2784161566 cites W2115115692 @default.
- W2784161566 cites W2115390147 @default.
- W2784161566 cites W2116226129 @default.
- W2784161566 cites W2120865569 @default.
- W2784161566 cites W2124630980 @default.
- W2784161566 cites W2125590017 @default.
- W2784161566 cites W2126360547 @default.
- W2784161566 cites W2129221594 @default.
- W2784161566 cites W2131656634 @default.
- W2784161566 cites W2143152183 @default.
- W2784161566 cites W2143452405 @default.
- W2784161566 cites W2152146866 @default.
- W2784161566 cites W2154940764 @default.
- W2784161566 cites W2154989816 @default.
- W2784161566 cites W2155601244 @default.
- W2784161566 cites W2157531541 @default.
- W2784161566 cites W2161744554 @default.
- W2784161566 cites W2169165033 @default.
- W2784161566 cites W2170464539 @default.
- W2784161566 cites W2171567992 @default.
- W2784161566 cites W2171731025 @default.
- W2784161566 cites W2184405267 @default.
- W2784161566 cites W2211987955 @default.
- W2784161566 cites W2250227412 @default.
- W2784161566 cites W2257239138 @default.
- W2784161566 cites W2272152428 @default.
- W2784161566 cites W2281368702 @default.
- W2784161566 cites W2294296138 @default.
- W2784161566 cites W2342846911 @default.
- W2784161566 cites W2345790997 @default.
- W2784161566 cites W2410501579 @default.
- W2784161566 cites W2427391176 @default.
- W2784161566 cites W2552162300 @default.
- W2784161566 cites W2559978823 @default.
- W2784161566 cites W2606365851 @default.
- W2784161566 cites W2615236945 @default.
- W2784161566 cites W2747084047 @default.
- W2784161566 doi "https://doi.org/10.1128/iai.00683-17" @default.
- W2784161566 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5913853" @default.
- W2784161566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29339462" @default.
- W2784161566 hasPublicationYear "2018" @default.
- W2784161566 type Work @default.
- W2784161566 sameAs 2784161566 @default.
- W2784161566 citedByCount "7" @default.
- W2784161566 countsByYear W27841615662020 @default.
- W2784161566 countsByYear W27841615662021 @default.
- W2784161566 countsByYear W27841615662022 @default.
- W2784161566 crossrefType "journal-article" @default.
- W2784161566 hasAuthorship W2784161566A5003472139 @default.
- W2784161566 hasAuthorship W2784161566A5016868088 @default.
- W2784161566 hasAuthorship W2784161566A5024372488 @default.
- W2784161566 hasBestOaLocation W27841615661 @default.