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- W2784163947 abstract "Cyclic nucleotide phosphodiesterase type 4 (PDE4), that controls intracellular level of cyclic nucleotide cAMP, has aroused scientific attention as a suitable target for anti-inflammatory therapy in respiratory diseases. Here we describe the development of two families of pyridazinone derivatives as potential PDE4 inhibitors and their evaluation as anti-inflammatory agents. Among these derivatives, 4,5-dihydropyridazinone representatives possess promising activity, selectivity towards PDE4 isoenzymes and are able to reduce IL-8 production by human primary polymorphonuclear cells." @default.
- W2784163947 created "2018-01-26" @default.
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- W2784163947 date "2018-02-01" @default.
- W2784163947 modified "2023-10-18" @default.
- W2784163947 title "Synthesis and biological evaluation of pyridazinone derivatives as potential anti-inflammatory agents" @default.
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- W2784163947 doi "https://doi.org/10.1016/j.ejmech.2018.01.035" @default.
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