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• W2784202279 endingPage "145" @default.
• W2784202279 startingPage "132" @default.
• W2784202279 abstract "Pyriproxyfen (2-[1-methyl-2-(4-phenoxyphenoxy) ethoxy] pyridine) (PPF), a pyridine-based pesticide widely used to control agricultural insect pests and mosquitoes in drinking water sources. However, its ecotoxicological data is limited in aquatic vertebrates particularly in fish. Hence, the present study aimed to evaluate the adverse effect of PPF in zebrafish embryo development (Danio rerio). In order to investigate the impact of PPF, embryos were exposed to 0.16, 0.33 and 1.66 μg/mL (0.52, 1.04 and 5.2 μM, respectively) for 96 hpf and various biomarker indices such as developmental toxicity (edema formation, hyperemia, heart size and scoliosis), oxidative stress (reactive oxygen species (ROS), lipid peroxidation (LPO) and nitric oxide (NO)), antioxidant responses (superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx) and reduced glutathione (GSH)), biochemical (lactate dehydrogenase (LDH) and acid phosphatase (AP)), neurotoxicity (acetylcholinesterase (AChE)), genotoxicity (apoptosis and DNA damage) and histopathological changes were determined. The results showed that severe developmental deformities and changes in heart rate were observed in embryos treated with highest (1.66 μg/mL) concentration than the control (P < 0.05). Heart size measurement showed that, significant change in heart size (P < 0.01) was observed in embryos of 96 hpf only at 1.66 μg/mL PPF exposure. The oxidative stress was apparent at highest test concentration (1.66 μg/mL) as reflected by the elevated ROS, LPO and NO and changes in antioxidant enzyme activities including SOD, CAT, GST and GPx (P < 0.05). Besides, GSH level and AChE activity were significantly lowered in 1.66 μg/mL PPF exposed group than the control. After 96 hpf of PPF exposure, no significant changes were found in AP activity whereas, a biphasic response was observed in the LDH activity. There was no genotoxic effect in embryos exposed to PPF at 0.16 and 0.33 μg/mL, while significant (P < 0.05) DNA damage and apoptosis were found in 1.66 μg/mL treated group. Histopathological analysis revealed that exposure to PPF at 1.66 μg/mL resulted in thinning of heart muscles, pericardial edema and hyperemia while there was no obvious changes were observed in other treatment groups. Hence, the results of the present study demonstrate that PPF could cause adverse effect on early developmental stages of zebrafish at higher concentration." @default.
• W2784202279 created "2018-01-26" @default.
• W2784202279 creator A5024596854 @default.
• W2784202279 creator A5035347761 @default.
• W2784202279 creator A5044771618 @default.
• W2784202279 creator A5068430453 @default.
• W2784202279 creator A5088244326 @default.
• W2784202279 date "2018-03-01" @default.
• W2784202279 modified "2023-10-15" @default.
• W2784202279 title "Toxicity assessment of pyriproxyfen in vertebrate model zebrafish embryos ( Danio rerio ): A multi biomarker study" @default.
• W2784202279 cites W1536923222 @default.
• W2784202279 cites W1539347645 @default.
• W2784202279 cites W1570704324 @default.
• W2784202279 cites W1775749144 @default.
• W2784202279 cites W1821918060 @default.
• W2784202279 cites W1963748853 @default.
• W2784202279 cites W1964556068 @default.
• W2784202279 cites W1969809278 @default.
• W2784202279 cites W1969904438 @default.
• W2784202279 cites W1971048984 @default.
• W2784202279 cites W197228448 @default.
• W2784202279 cites W1975692305 @default.
• W2784202279 cites W1977318871 @default.
• W2784202279 cites W1978806457 @default.
• W2784202279 cites W1981239255 @default.
• W2784202279 cites W1982600220 @default.
• W2784202279 cites W1983135948 @default.
• W2784202279 cites W1985812792 @default.
• W2784202279 cites W1986020857 @default.
• W2784202279 cites W1988390723 @default.
• W2784202279 cites W1989239048 @default.
• W2784202279 cites W1990351437 @default.
• W2784202279 cites W1991293114 @default.
• W2784202279 cites W1994303699 @default.
• W2784202279 cites W1996044256 @default.
• W2784202279 cites W2004367631 @default.
• W2784202279 cites W2005758092 @default.
• W2784202279 cites W2006325976 @default.
• W2784202279 cites W2010175494 @default.
• W2784202279 cites W2010732217 @default.
• W2784202279 cites W2010965103 @default.
• W2784202279 cites W2011188574 @default.
• W2784202279 cites W2013556000 @default.
• W2784202279 cites W2018662920 @default.
• W2784202279 cites W2020469902 @default.
• W2784202279 cites W2023012362 @default.
• W2784202279 cites W2023973240 @default.
• W2784202279 cites W2025448936 @default.
• W2784202279 cites W2026120735 @default.
• W2784202279 cites W2033855679 @default.
• W2784202279 cites W2038241119 @default.
• W2784202279 cites W2039071198 @default.
• W2784202279 cites W2039252349 @default.
• W2784202279 cites W2043821272 @default.
• W2784202279 cites W2053471764 @default.
• W2784202279 cites W2054416568 @default.
• W2784202279 cites W2056149721 @default.
• W2784202279 cites W2056349805 @default.
• W2784202279 cites W2063774874 @default.
• W2784202279 cites W2065288843 @default.
• W2784202279 cites W2065591914 @default.
• W2784202279 cites W2065852162 @default.
• W2784202279 cites W2066448156 @default.
• W2784202279 cites W2067114947 @default.
• W2784202279 cites W2068026234 @default.
• W2784202279 cites W2068893061 @default.
• W2784202279 cites W2073404756 @default.
• W2784202279 cites W2077854734 @default.
• W2784202279 cites W2086111284 @default.
• W2784202279 cites W2088708637 @default.
• W2784202279 cites W2089869610 @default.
• W2784202279 cites W2091845488 @default.
• W2784202279 cites W2092602838 @default.
• W2784202279 cites W2092629964 @default.
• W2784202279 cites W2096795975 @default.
• W2784202279 cites W2098839794 @default.
• W2784202279 cites W2105732317 @default.
• W2784202279 cites W2108791332 @default.
• W2784202279 cites W2110567633 @default.
• W2784202279 cites W2119125561 @default.
• W2784202279 cites W2125349610 @default.
• W2784202279 cites W2125737305 @default.
• W2784202279 cites W2137340670 @default.
• W2784202279 cites W2140176615 @default.
• W2784202279 cites W2148435273 @default.
• W2784202279 cites W2149005661 @default.
• W2784202279 cites W2150546617 @default.
• W2784202279 cites W2158406641 @default.
• W2784202279 cites W2159371794 @default.
• W2784202279 cites W2162060922 @default.
• W2784202279 cites W2164610579 @default.
• W2784202279 cites W2165132551 @default.
• W2784202279 cites W2167999754 @default.
• W2784202279 cites W2168087907 @default.
• W2784202279 cites W2173390200 @default.
• W2784202279 cites W2174879024 @default.
• W2784202279 cites W2318675639 @default.
• W2784202279 cites W2408962988 @default.

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