FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2784207848> ?p ?o ?g. }

• W2784207848 abstract "Astrocytes have long been regarded as essentially unexcitable cells that do not contribute to active signaling and information processing in the brain. Contrary to this classical view, it is now firmly established that astrocytes can specifically respond to glutamate released from neurons. Astrocyte glutamate signaling is initiated upon binding of glutamate to ionotropic and/or metabotropic receptors, which can result in calcium signaling, a major form of glial excitability. Release of so-called gliotransmitters like glutamate, ATP and D-serine from astrocytes in response to activation of glutamate receptors has been demonstrated to modulate various aspects of neuronal function in the hippocampus. In addition to receptors, glutamate binds to high-affinity, sodium-dependent transporters, which results in rapid buffering of synaptically-released glutamate, followed by its removal from the synaptic cleft through uptake into astrocytes. The degree to which astrocytes modulate and control extracellular glutamate levels through glutamate transporters depends on their expression levels and on the ionic driving forces that decrease with ongoing activity. Another major determinant of astrocytic control of glutamate levels could be the precise morphological arrangement of fine perisynaptic processes close to synapses, defining the diffusional distance for glutamate, and the spatial proximity of transporters in relation to the synaptic cleft. In this review, we will present an overview of the mechanisms and physiological role of glutamate-induced ion signaling in astrocytes in the hippocampus as mediated by receptors and transporters. Moreover, we will discuss the relevance of astroglial glutamate uptake for extracellular glutamate homeostasis, focusing on how activity-induced dynamic changes of perisynaptic processes could shape synaptic transmission at glutamatergic synapses." @default.
• W2784207848 created "2018-01-26" @default.
• W2784207848 creator A5002421498 @default.
• W2784207848 creator A5004662891 @default.
• W2784207848 creator A5015322241 @default.
• W2784207848 creator A5029095407 @default.
• W2784207848 creator A5033497484 @default.
• W2784207848 creator A5074413118 @default.
• W2784207848 date "2018-01-17" @default.
• W2784207848 modified "2023-10-18" @default.
• W2784207848 title "Astroglial Glutamate Signaling and Uptake in the Hippocampus" @default.
• W2784207848 cites W1497360520 @default.
• W2784207848 cites W1505675853 @default.
• W2784207848 cites W1508839941 @default.
• W2784207848 cites W1509628792 @default.
• W2784207848 cites W1520391040 @default.
• W2784207848 cites W1528575744 @default.
• W2784207848 cites W1533853049 @default.
• W2784207848 cites W1549972124 @default.
• W2784207848 cites W1551725092 @default.
• W2784207848 cites W1554041387 @default.
• W2784207848 cites W1571617145 @default.
• W2784207848 cites W1572171312 @default.
• W2784207848 cites W1583603147 @default.
• W2784207848 cites W1591369895 @default.
• W2784207848 cites W1593228500 @default.
• W2784207848 cites W1594253922 @default.
• W2784207848 cites W1605749484 @default.
• W2784207848 cites W1629378997 @default.
• W2784207848 cites W1646272776 @default.
• W2784207848 cites W1696619846 @default.
• W2784207848 cites W1845163922 @default.
• W2784207848 cites W1882809545 @default.
• W2784207848 cites W1915126090 @default.
• W2784207848 cites W1960685535 @default.
• W2784207848 cites W1966846060 @default.
• W2784207848 cites W1967100281 @default.
• W2784207848 cites W1968579019 @default.
• W2784207848 cites W1969166715 @default.
• W2784207848 cites W1972077052 @default.
• W2784207848 cites W1972161610 @default.
• W2784207848 cites W1972784441 @default.
• W2784207848 cites W1973388583 @default.
• W2784207848 cites W1973839541 @default.
• W2784207848 cites W1975888261 @default.
• W2784207848 cites W1976366566 @default.
• W2784207848 cites W1976754780 @default.
• W2784207848 cites W1977976400 @default.
• W2784207848 cites W1978266024 @default.
• W2784207848 cites W1979106875 @default.
• W2784207848 cites W1979363543 @default.
• W2784207848 cites W1980090196 @default.
• W2784207848 cites W1980617113 @default.
• W2784207848 cites W1980816722 @default.
• W2784207848 cites W1980979304 @default.
• W2784207848 cites W1981763442 @default.
• W2784207848 cites W1983379809 @default.
• W2784207848 cites W1984170477 @default.
• W2784207848 cites W1985985003 @default.
• W2784207848 cites W1986195427 @default.
• W2784207848 cites W1989539506 @default.
• W2784207848 cites W1990978305 @default.
• W2784207848 cites W1991517801 @default.
• W2784207848 cites W1992521533 @default.
• W2784207848 cites W1996730767 @default.
• W2784207848 cites W1998337135 @default.
• W2784207848 cites W1998432972 @default.
• W2784207848 cites W1999613366 @default.
• W2784207848 cites W1999736911 @default.
• W2784207848 cites W2001223958 @default.
• W2784207848 cites W2001729546 @default.
• W2784207848 cites W2002247284 @default.
• W2784207848 cites W2003059369 @default.
• W2784207848 cites W2003410399 @default.
• W2784207848 cites W2004195391 @default.
• W2784207848 cites W2006154748 @default.
• W2784207848 cites W2007761900 @default.
• W2784207848 cites W2008033907 @default.
• W2784207848 cites W2008264883 @default.
• W2784207848 cites W2009812273 @default.
• W2784207848 cites W2010078015 @default.
• W2784207848 cites W2011849966 @default.
• W2784207848 cites W2012038360 @default.
• W2784207848 cites W2013479315 @default.
• W2784207848 cites W2015541518 @default.
• W2784207848 cites W2016379134 @default.
• W2784207848 cites W2016575029 @default.
• W2784207848 cites W2017349018 @default.
• W2784207848 cites W2017934591 @default.
• W2784207848 cites W2018149549 @default.
• W2784207848 cites W2020383525 @default.
• W2784207848 cites W2020603406 @default.
• W2784207848 cites W2021882008 @default.
• W2784207848 cites W2022594235 @default.
• W2784207848 cites W2025498751 @default.
• W2784207848 cites W2030352252 @default.
• W2784207848 cites W2030787126 @default.
• W2784207848 cites W2032154466 @default.
• W2784207848 cites W2034003277 @default.
• W2784207848 cites W2034171869 @default.

• next