Matches in SemOpenAlex for { <https://semopenalex.org/work/W2784213104> ?p ?o ?g. }
- W2784213104 endingPage "e0190449" @default.
- W2784213104 startingPage "e0190449" @default.
- W2784213104 abstract "Following traumatic brain injury (TBI) neurological damage is ongoing through a complex cascade of primary and secondary injury events in the ensuing minutes, days and weeks. The delayed nature of secondary injury provides a valuable window of opportunity to limit the consequences with a timely treatment. Recently, the amyloid precursor protein (APP) and its derivative APP96-110 have shown encouraging neuroprotective activity following TBI following an intracerebroventricular administration. Nevertheless, its broader clinical utility would be enhanced by an intravenous (IV) administration. This study assessed the efficacy of IV APP96-110, where a dose-response for a single dose of 0.005mg/kg– 0.5mg/kg APP96-110 at either 30 minutes or 5 hours following moderate-severe diffuse impact-acceleration injury was performed. Male Sprague-Dawley rats were assessed daily for 3 or 7 days on the rotarod to examine motor outcome, with a separate cohort of animals utilised for immunohistochemistry analysis 3 days post-TBI to assess axonal injury and neuroinflammation. Animals treated with 0.05mg/kg or 0.5mg/kg APP96-110 after 30 minutes demonstrated significant improvements in motor outcome. This was accompanied by a reduction in axonal injury and neuroinflammation in the corpus callosum at 3 days post-TBI, whereas 0.005mg/kg had no effect. In contrast, treatment with 0.005m/kg or 0.5mg/kg APP96-110 at 5 hours post-TBI demonstrated significant improvements in motor outcome over 3 days, which was accompanied by a reduction in axonal injury in the corpus callosum. This demonstrates that APP96-110 remains efficacious for up to 5 hours post-TBI when administered IV, and supports its development as a novel therapeutic compound following TBI." @default.
- W2784213104 created "2018-01-26" @default.
- W2784213104 creator A5007621123 @default.
- W2784213104 creator A5035738047 @default.
- W2784213104 creator A5042740778 @default.
- W2784213104 creator A5057319291 @default.
- W2784213104 creator A5072791650 @default.
- W2784213104 creator A5073903571 @default.
- W2784213104 creator A5088446497 @default.
- W2784213104 date "2018-01-10" @default.
- W2784213104 modified "2023-10-10" @default.
- W2784213104 title "The amyloid precursor protein derivative, APP96-110, is efficacious following intravenous administration after traumatic brain injury" @default.
- W2784213104 cites W1485425418 @default.
- W2784213104 cites W1532138628 @default.
- W2784213104 cites W1602123250 @default.
- W2784213104 cites W1933062072 @default.
- W2784213104 cites W1966197259 @default.
- W2784213104 cites W1970107990 @default.
- W2784213104 cites W1970845004 @default.
- W2784213104 cites W1972468142 @default.
- W2784213104 cites W1979480311 @default.
- W2784213104 cites W1984305500 @default.
- W2784213104 cites W1986550170 @default.
- W2784213104 cites W1995395034 @default.
- W2784213104 cites W2001445086 @default.
- W2784213104 cites W2016108891 @default.
- W2784213104 cites W2023540371 @default.
- W2784213104 cites W2028301250 @default.
- W2784213104 cites W2036058710 @default.
- W2784213104 cites W2042822864 @default.
- W2784213104 cites W2048950034 @default.
- W2784213104 cites W2049539275 @default.
- W2784213104 cites W2058411142 @default.
- W2784213104 cites W2061812167 @default.
- W2784213104 cites W2066346909 @default.
- W2784213104 cites W2067448822 @default.
- W2784213104 cites W2068330750 @default.
- W2784213104 cites W2077935628 @default.
- W2784213104 cites W2086234077 @default.
- W2784213104 cites W2086651792 @default.
- W2784213104 cites W2088301798 @default.
- W2784213104 cites W2091953894 @default.
- W2784213104 cites W2103044571 @default.
- W2784213104 cites W2112462557 @default.
- W2784213104 cites W2128356132 @default.
- W2784213104 cites W2136697740 @default.
- W2784213104 cites W2137529477 @default.
- W2784213104 cites W2140729052 @default.
- W2784213104 cites W2154815136 @default.
- W2784213104 cites W2161340781 @default.
- W2784213104 cites W2169924162 @default.
- W2784213104 cites W2170670144 @default.
- W2784213104 cites W2330745701 @default.
- W2784213104 cites W2501590294 @default.
- W2784213104 cites W3023566214 @default.
- W2784213104 doi "https://doi.org/10.1371/journal.pone.0190449" @default.
- W2784213104 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5761886" @default.
- W2784213104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29320530" @default.
- W2784213104 hasPublicationYear "2018" @default.
- W2784213104 type Work @default.
- W2784213104 sameAs 2784213104 @default.
- W2784213104 citedByCount "15" @default.
- W2784213104 countsByYear W27842131042018 @default.
- W2784213104 countsByYear W27842131042019 @default.
- W2784213104 countsByYear W27842131042020 @default.
- W2784213104 countsByYear W27842131042022 @default.
- W2784213104 countsByYear W27842131042023 @default.
- W2784213104 crossrefType "journal-article" @default.
- W2784213104 hasAuthorship W2784213104A5007621123 @default.
- W2784213104 hasAuthorship W2784213104A5035738047 @default.
- W2784213104 hasAuthorship W2784213104A5042740778 @default.
- W2784213104 hasAuthorship W2784213104A5057319291 @default.
- W2784213104 hasAuthorship W2784213104A5072791650 @default.
- W2784213104 hasAuthorship W2784213104A5073903571 @default.
- W2784213104 hasAuthorship W2784213104A5088446497 @default.
- W2784213104 hasBestOaLocation W27842131041 @default.
- W2784213104 hasConcept C118552586 @default.
- W2784213104 hasConcept C126322002 @default.
- W2784213104 hasConcept C142724271 @default.
- W2784213104 hasConcept C25498285 @default.
- W2784213104 hasConcept C2776914184 @default.
- W2784213104 hasConcept C2778183499 @default.
- W2784213104 hasConcept C2781017439 @default.
- W2784213104 hasConcept C42219234 @default.
- W2784213104 hasConcept C71924100 @default.
- W2784213104 hasConcept C87753298 @default.
- W2784213104 hasConcept C98274493 @default.
- W2784213104 hasConceptScore W2784213104C118552586 @default.
- W2784213104 hasConceptScore W2784213104C126322002 @default.
- W2784213104 hasConceptScore W2784213104C142724271 @default.
- W2784213104 hasConceptScore W2784213104C25498285 @default.
- W2784213104 hasConceptScore W2784213104C2776914184 @default.
- W2784213104 hasConceptScore W2784213104C2778183499 @default.
- W2784213104 hasConceptScore W2784213104C2781017439 @default.
- W2784213104 hasConceptScore W2784213104C42219234 @default.
- W2784213104 hasConceptScore W2784213104C71924100 @default.
- W2784213104 hasConceptScore W2784213104C87753298 @default.
- W2784213104 hasConceptScore W2784213104C98274493 @default.