FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2784328123> ?p ?o ?g. }

• W2784328123 endingPage "1188" @default.
• W2784328123 startingPage "1182" @default.
• W2784328123 abstract "We assessed the association between 1,414 single nucleotide polymorphisms (SNPs) in genes involved in synthesis and metabolism of steroid hormones and insulin-like growth factor 1, and risk of breast cancer in situ (BCIS), with the aim of determining whether any of these were disease specific. This was carried out using 1,062 BCIS cases and 10,126 controls as well as 6,113 invasive breast cancer cases from the Breast and Prostate Cancer Cohort Consortium (BPC3). Three SNPs showed at least one nominally significant association in homozygous minor versus homozygous major models. ACVR2A-rs2382112 (ORhom = 3.05, 95%CI = 1.72–5.44, Phom = 1.47 × 10−4), MAST2-rs12124649 (ORhom = 1.73, 95% CI =1.18–2.54, Phom = 5.24 × 10−3), and INSR-rs10500204 (ORhom = 1.96, 95% CI = 1.44–2.67, Phom=1.68 × 10−5) were associated with increased risk of BCIS; however, only the latter association was significant after correcting for multiple testing. Furthermore, INSR-rs10500204 was more strongly associated with the risk of BCIS than invasive disease in case-only analyses using the homozygous minor versus homozygous major model (ORhom = 1.78, 95% CI = 1.30–2.44, Phom = 3.23 × 10−4). The SNP INSR-rs10500204 is located in an intron of the INSR gene and is likely to affect binding of the promyelocytic leukemia (PML) protein. The PML gene is known as a tumor suppressor and growth regulator in cancer. However, it is not clear on what pathway the A-allele of rs10500204 could operate to influence the binding of the protein. Hence, functional studies are warranted to investigate this further." @default.
• W2784328123 created "2018-01-26" @default.
• W2784328123 creator A5004285350 @default.
• W2784328123 creator A5013210350 @default.
• W2784328123 creator A5019133187 @default.
• W2784328123 creator A5021761022 @default.
• W2784328123 creator A5025189456 @default.
• W2784328123 creator A5027449085 @default.
• W2784328123 creator A5033124357 @default.
• W2784328123 creator A5038423396 @default.
• W2784328123 creator A5040933938 @default.
• W2784328123 creator A5048695529 @default.
• W2784328123 creator A5053074659 @default.
• W2784328123 creator A5053374075 @default.
• W2784328123 creator A5057439369 @default.
• W2784328123 creator A5060049615 @default.
• W2784328123 creator A5063459619 @default.
• W2784328123 creator A5070690527 @default.
• W2784328123 creator A5070896103 @default.
• W2784328123 creator A5077064078 @default.
• W2784328123 creator A5080921373 @default.
• W2784328123 creator A5083450375 @default.
• W2784328123 creator A5086826772 @default.
• W2784328123 creator A5090744975 @default.
• W2784328123 creator A5091068421 @default.
• W2784328123 creator A5091653870 @default.
• W2784328123 date "2017-11-17" @default.
• W2784328123 modified "2023-10-16" @default.
• W2784328123 title "A comprehensive analysis of polymorphic variants in steroid hormone and insulin-like growth factor-1 metabolism and risk of in situ breast cancer: Results from the Breast and Prostate Cancer Cohort Consortium" @default.
• W2784328123 cites W1528494173 @default.
• W2784328123 cites W1850198354 @default.
• W2784328123 cites W1854253459 @default.
• W2784328123 cites W1869567870 @default.
• W2784328123 cites W1875199757 @default.
• W2784328123 cites W1981061928 @default.
• W2784328123 cites W1994664175 @default.
• W2784328123 cites W2002715948 @default.
• W2784328123 cites W2006423274 @default.
• W2784328123 cites W2031772624 @default.
• W2784328123 cites W2037209340 @default.
• W2784328123 cites W2047589055 @default.
• W2784328123 cites W2059638779 @default.
• W2784328123 cites W2077326342 @default.
• W2784328123 cites W2079712106 @default.
• W2784328123 cites W2096433887 @default.
• W2784328123 cites W2125583020 @default.
• W2784328123 cites W2126717458 @default.
• W2784328123 cites W2135184355 @default.
• W2784328123 cites W2135665336 @default.
• W2784328123 cites W2141820415 @default.
• W2784328123 cites W2151409620 @default.
• W2784328123 cites W2160835537 @default.
• W2784328123 cites W2163037142 @default.
• W2784328123 cites W2165084094 @default.
• W2784328123 cites W2167342921 @default.
• W2784328123 cites W2168986424 @default.
• W2784328123 cites W2248907500 @default.
• W2784328123 cites W2287794423 @default.
• W2784328123 cites W4256477026 @default.
• W2784328123 cites W635586423 @default.
• W2784328123 doi "https://doi.org/10.1002/ijc.31145" @default.
• W2784328123 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6610718" @default.
• W2784328123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29114882" @default.
• W2784328123 hasPublicationYear "2017" @default.
• W2784328123 type Work @default.
• W2784328123 sameAs 2784328123 @default.
• W2784328123 citedByCount "0" @default.
• W2784328123 crossrefType "journal-article" @default.
• W2784328123 hasAuthorship W2784328123A5004285350 @default.
• W2784328123 hasAuthorship W2784328123A5013210350 @default.
• W2784328123 hasAuthorship W2784328123A5019133187 @default.
• W2784328123 hasAuthorship W2784328123A5021761022 @default.
• W2784328123 hasAuthorship W2784328123A5025189456 @default.
• W2784328123 hasAuthorship W2784328123A5027449085 @default.
• W2784328123 hasAuthorship W2784328123A5033124357 @default.
• W2784328123 hasAuthorship W2784328123A5038423396 @default.
• W2784328123 hasAuthorship W2784328123A5040933938 @default.
• W2784328123 hasAuthorship W2784328123A5048695529 @default.
• W2784328123 hasAuthorship W2784328123A5053074659 @default.
• W2784328123 hasAuthorship W2784328123A5053374075 @default.
• W2784328123 hasAuthorship W2784328123A5057439369 @default.
• W2784328123 hasAuthorship W2784328123A5060049615 @default.
• W2784328123 hasAuthorship W2784328123A5063459619 @default.
• W2784328123 hasAuthorship W2784328123A5070690527 @default.
• W2784328123 hasAuthorship W2784328123A5070896103 @default.
• W2784328123 hasAuthorship W2784328123A5077064078 @default.
• W2784328123 hasAuthorship W2784328123A5080921373 @default.
• W2784328123 hasAuthorship W2784328123A5083450375 @default.
• W2784328123 hasAuthorship W2784328123A5086826772 @default.
• W2784328123 hasAuthorship W2784328123A5090744975 @default.
• W2784328123 hasAuthorship W2784328123A5091068421 @default.
• W2784328123 hasAuthorship W2784328123A5091653870 @default.
• W2784328123 hasBestOaLocation W27843281231 @default.
• W2784328123 hasConcept C104317684 @default.
• W2784328123 hasConcept C121608353 @default.
• W2784328123 hasConcept C126322002 @default.
• W2784328123 hasConcept C134018914 @default.
• W2784328123 hasConcept C135763542 @default.

• next