Matches in SemOpenAlex for { <https://semopenalex.org/work/W2784328385> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2784328385 abstract "Background and Objectives: There is increase prevalence of gastric ulcer in the society, but the drugs that are sensitive for radical cure are not screened with physiologic markers such which affect proper management of the disease. The objective of the study is to relate various sources or organ specific templates: gastrin, histamine and prostaglandin relating with the disease in evaluating the potencies of cimetidine, ranitidine and omeprazole for best choice of the drugs in gastric ulcer disease treatment.Material and Methods: Plasma, gastric and antral prostaglandins, histamine and gastrin levels were studied in ninety-six (96), male and female Swiss albino rats for 28 days, using high performance liquid chromatography.Results: Male and female rats with gastric ulcer treated with cimetidine, omepraszole and ranitidine showed no significant difference (P>0.5) in gastrin and the drug groups in plasma, gastric and antral concentrations. But, there was significant difference (P<0.05) in histamine levels between cimetidine, omeprazole and ranitidine in their gastric and plasma concentration. There was no significant difference (P>0.05) in prostaglandin values between cimetidine, omeprazole and ranitidine. Also there was no significant difference (P>0.05) in gastric and plasma levels of gastrin, histamine and prostaglandin between 7, 14, 21 and 28 days treatment period. But, there was significant difference (P<0.05) in antral concentration of gastrin, histamines and prostaglandin between the drug groups. However, there was no significant difference (P>0.05) in antral gastrin between male and female rats in cimetidine and ranitidine treatment. The three drugs were associated with high levels of gastrin, histamine, low prostaglandin though cimetidine showed higher concentration of prostaglandin.Conclusion: It is concluded that gastrin, histamine and prostaglandin are sensitive indicators in evaluating anti-ulcerogenic drugs efficacies.Janaki Medical College Journal of Medical Sciences (2017) Vol. 5(2): 5-12" @default.
- W2784328385 created "2018-01-26" @default.
- W2784328385 creator A5016885821 @default.
- W2784328385 creator A5090162063 @default.
- W2784328385 date "2018-01-16" @default.
- W2784328385 modified "2023-09-25" @default.
- W2784328385 title "Gastrin, Histamine Prostaglandin: Indicators for assessing efficacy of cimetidine, Omeprazole and Ranitidine in Gastric Ulcer Treatment" @default.
- W2784328385 doi "https://doi.org/10.3126/jmcjms.v5i2.19011" @default.
- W2784328385 hasPublicationYear "2018" @default.
- W2784328385 type Work @default.
- W2784328385 sameAs 2784328385 @default.
- W2784328385 citedByCount "0" @default.
- W2784328385 crossrefType "journal-article" @default.
- W2784328385 hasAuthorship W2784328385A5016885821 @default.
- W2784328385 hasAuthorship W2784328385A5090162063 @default.
- W2784328385 hasBestOaLocation W27843283851 @default.
- W2784328385 hasConcept C1122143 @default.
- W2784328385 hasConcept C126322002 @default.
- W2784328385 hasConcept C131253125 @default.
- W2784328385 hasConcept C134018914 @default.
- W2784328385 hasConcept C2776986829 @default.
- W2784328385 hasConcept C2777445857 @default.
- W2784328385 hasConcept C2777498785 @default.
- W2784328385 hasConcept C2779422922 @default.
- W2784328385 hasConcept C2780664492 @default.
- W2784328385 hasConcept C2780719153 @default.
- W2784328385 hasConcept C49039625 @default.
- W2784328385 hasConcept C71924100 @default.
- W2784328385 hasConcept C90924648 @default.
- W2784328385 hasConceptScore W2784328385C1122143 @default.
- W2784328385 hasConceptScore W2784328385C126322002 @default.
- W2784328385 hasConceptScore W2784328385C131253125 @default.
- W2784328385 hasConceptScore W2784328385C134018914 @default.
- W2784328385 hasConceptScore W2784328385C2776986829 @default.
- W2784328385 hasConceptScore W2784328385C2777445857 @default.
- W2784328385 hasConceptScore W2784328385C2777498785 @default.
- W2784328385 hasConceptScore W2784328385C2779422922 @default.
- W2784328385 hasConceptScore W2784328385C2780664492 @default.
- W2784328385 hasConceptScore W2784328385C2780719153 @default.
- W2784328385 hasConceptScore W2784328385C49039625 @default.
- W2784328385 hasConceptScore W2784328385C71924100 @default.
- W2784328385 hasConceptScore W2784328385C90924648 @default.
- W2784328385 hasLocation W27843283851 @default.
- W2784328385 hasOpenAccess W2784328385 @default.
- W2784328385 hasPrimaryLocation W27843283851 @default.
- W2784328385 hasRelatedWork W1605147008 @default.
- W2784328385 hasRelatedWork W1967848865 @default.
- W2784328385 hasRelatedWork W1998708329 @default.
- W2784328385 hasRelatedWork W2003991866 @default.
- W2784328385 hasRelatedWork W2009162857 @default.
- W2784328385 hasRelatedWork W2020545274 @default.
- W2784328385 hasRelatedWork W2041044408 @default.
- W2784328385 hasRelatedWork W2050518330 @default.
- W2784328385 hasRelatedWork W2051140372 @default.
- W2784328385 hasRelatedWork W2052143930 @default.
- W2784328385 hasRelatedWork W2056688340 @default.
- W2784328385 hasRelatedWork W2093543087 @default.
- W2784328385 hasRelatedWork W2123902199 @default.
- W2784328385 hasRelatedWork W2146738478 @default.
- W2784328385 hasRelatedWork W2161958363 @default.
- W2784328385 hasRelatedWork W2314014266 @default.
- W2784328385 hasRelatedWork W2359307224 @default.
- W2784328385 hasRelatedWork W2404254403 @default.
- W2784328385 hasRelatedWork W2414685497 @default.
- W2784328385 hasRelatedWork W2795310158 @default.
- W2784328385 isParatext "false" @default.
- W2784328385 isRetracted "false" @default.
- W2784328385 magId "2784328385" @default.
- W2784328385 workType "article" @default.