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- W2784347117 abstract "We examined the collisionally activated dissociation (CAD) pathways of protonated 2=-deoxycytidine (dC), 5-formyl-2=-deoxycytidine (5-FmdC), 5-hydroxy-2=-deoxycytidine (5-OHdC), 5-hydroxymethyl-2=-deoxycytidine (5-HmdC), and their corresponding stable isotope-labeled compounds to gain insights into the effects of modifications on the fragmentation pathways of the pyrimidine bases. Multi-stage MS (MS n ) results showed that protonated cytosine, its 5-hydroxyland 5-hydroxymethyl-substituted derivatives, but not its 5-formyl-substituted analog, could undergo Dimroth-like rearrangement in the gas-phase. The elimination of HNCO was one of the major fragmentation pathways observed for the protonated ions of all dC derivatives except for 5-hydroxymethylcytosine, which underwent this loss only after a H2O molecule had been eliminated. In addition, the protonated cytosine and 5-hydroxycytosine can undergo a facile elimination of NH3 molecule. This loss, however, was not observed for protonated 5-hydroxymethylcytosine, 5-formylcytosine, and their uracil analogs. Taken together, our study demonstrated that modifications could alter markedly the CAD patterns of the protonated pyrimidine bases. The results from this study provided a basis for the identifications of other modified pyrimidine bases/nucleosides by tandem mass spectrometry. (J Am Soc Mass Spectrom 2006, 17, 1335–1341) © 2006 American Society for Mass Spectrometry" @default.
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- W2784347117 date "2006-01-01" @default.
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- W2784347117 title "FOCUS :N UCLEIC ACIDS IN MASS SPECTROMETRY Collisionally Activated Dissociation of Protonated 2=-Deoxycytidine, 2=-Deoxyuridine, and their Oxidatively Damaged Derivatives" @default.
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