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- W278436245 abstract "Objective:To observe the effects of L-carnitine(LC) on the renal ultrastructure damage induced by cisplatin(DDP).Methods:Female adult Wistar rats were randomly divided into control group,DDP group,LC+DDP group and each group consisted of 12 animals.Rats in control group and DDP group were fed a common diet while those in LC+DDP group were added 1% LC into their common diet.After feed for 7 days,animals in DDP group and LC+DDP group received cisplatin intraperitoneal injection at 5 mg/kg body weight while those in control group were given normal saline.On the fourth day after injection,all rats were killed,and the renal morphological structures were observed under light microscope and transmission electron microscope(TEM).Results:The pathological slices indicated that the glomcrulus structures were complete in DDP group,but the vacuolar degeneration and necrosis in endothelial cells of proximal convoluted tubule and protein casts in renal tubules were found.However,these changes were significantly improved in LC+DDP group.Furthermore,ultrastructures under TEM demonstrated that swelling,vacuolar degeneration,disaggregation and cristae fragmentation and absence of mitochondria were less apparent in LC+DDP group than those in DDP group.Conclusion:To some extent,a preventative dietary supplementation with LC might protect renal pathological structure and ultrastructure from the damages induced by cisplatin in rats." @default.
- W278436245 created "2016-06-24" @default.
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- W278436245 date "2009-01-01" @default.
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- W278436245 title "Effects of L-carnitine on rectal ultrastructure damage induced by cisplatin in rats." @default.
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