FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2784631270> ?p ?o ?g. }

• W2784631270 abstract "ABSTRACT Background Irinotecan (IR) or oxaliplatin (OX)-based regimens optionally combined with anti-VEGF or anti-EGFR Target Therapies (TT) are used as preoperative treatment for metastatic colorectal patients before resection of CRCM. Best combination remains unclear. The study purpose was to compare PR observed on resected CRCM after different preoperative treatments. Methods 114 patients engaged for CRCM resection after 2005 were included in this retrospective analysis. PR was evaluated on 296 resected CRCM according to the pathological Tumor Regression Grading scale (TRG), grading PR from complete (TRG1) to absent (TRG5). Mean TRG of resected metastasis was compared based on Kruskall-Wallis and Mann-Whitney tests. Cumulative PFS were calculated by Kaplan-Meir method and compared by log-rank test. Results 92/114 patients were preoperatively treated. Mean TRG after OX without TT was better than mean TRG after IR without TT (p = .044). No difference was observed between mean TRG after chemotherapy alone compared to mean TRG after chemotherapy + anti-VEGF (p = .53) or to mean TRG after chemotherapy + anti-EGFR (p = .39). Subgroup analysis revealed that mean TRG after IR + anti-EGFR was better than mean TRG after OX + anti-EGFR (p = .031), and that mean TRG after OX + anti-VEGF was better than mean TRG after IR + anti-VEGF (p = .001). PFS analysis for the 92 preoperatively treated patients revealed that 13 patients with major PR (TRG ≤ 2), had a significantly improved PFS compared to 79 patients with minor or no PR (TRG > 2) (median PFS= 33.7 vs 22.9 month p= .018). Conclusion PR observed on resected CRCM after a preoperative treatment does not seem to be linked to the TT (anti-VEGF or anti-EGFR) but rather to the chemotherapy/TT association with a significant advantage for OX + anti-VEGF or IR + anti-EGFR combinations. Preoperative strategy Patients (n) Metastases (n) TRG mean 95% CI No treatment 22 54 4.33 4.11- 4.55 Chemo alone 38 86 3.19 2.95 - 3.43 OX 28 68 3.16 2.89-3.43 IR 8 11 3.91 3.44-4.38 Other 2 7 ND ND Anti-VEGF + chemo 38 120 3.32 3.10 - 3.54 OX 8 27 2.63 2.18 - 3.08 IR 29 80 3.53 3.27 - 3.78 Other 1 13 ND ND Anti-EGFR + chemo 16 36 2.97 2.50 - 3.44 OX 9 16 3.56 2.98 - 4.15 IR 6 19 2.47 1.77 - 3.18 Other 1 1 ND ND Disclosure All authors have declared no conflicts of interest." @default.
• W2784631270 created "2018-02-02" @default.
• W2784631270 creator A5013575589 @default.
• W2784631270 creator A5016173075 @default.
• W2784631270 creator A5019452072 @default.
• W2784631270 creator A5041847210 @default.
• W2784631270 creator A5044214543 @default.
• W2784631270 creator A5051098584 @default.
• W2784631270 creator A5052684432 @default.
• W2784631270 creator A5055269253 @default.
• W2784631270 creator A5082219176 @default.
• W2784631270 creator A5082757733 @default.
• W2784631270 date "2012-09-01" @default.
• W2784631270 modified "2023-09-28" @default.
• W2784631270 title "Comparison of Pathological Responses (PR) Observed on Colorectal Cancer Metastases (CRCM) Resected After Different Preoperative Treatments" @default.
• W2784631270 doi "https://doi.org/10.1016/s0923-7534(20)33190-2" @default.
• W2784631270 hasPublicationYear "2012" @default.
• W2784631270 type Work @default.
• W2784631270 sameAs 2784631270 @default.
• W2784631270 citedByCount "0" @default.
• W2784631270 crossrefType "journal-article" @default.
• W2784631270 hasAuthorship W2784631270A5013575589 @default.
• W2784631270 hasAuthorship W2784631270A5016173075 @default.
• W2784631270 hasAuthorship W2784631270A5019452072 @default.
• W2784631270 hasAuthorship W2784631270A5041847210 @default.
• W2784631270 hasAuthorship W2784631270A5044214543 @default.
• W2784631270 hasAuthorship W2784631270A5051098584 @default.
• W2784631270 hasAuthorship W2784631270A5052684432 @default.
• W2784631270 hasAuthorship W2784631270A5055269253 @default.
• W2784631270 hasAuthorship W2784631270A5082219176 @default.
• W2784631270 hasAuthorship W2784631270A5082757733 @default.
• W2784631270 hasBestOaLocation W27846312701 @default.
• W2784631270 hasConcept C121608353 @default.
• W2784631270 hasConcept C126322002 @default.
• W2784631270 hasConcept C127413603 @default.
• W2784631270 hasConcept C147176958 @default.
• W2784631270 hasConcept C2776694085 @default.
• W2784631270 hasConcept C2777286243 @default.
• W2784631270 hasConcept C2780259306 @default.
• W2784631270 hasConcept C526805850 @default.
• W2784631270 hasConcept C71924100 @default.
• W2784631270 hasConcept C90924648 @default.
• W2784631270 hasConceptScore W2784631270C121608353 @default.
• W2784631270 hasConceptScore W2784631270C126322002 @default.
• W2784631270 hasConceptScore W2784631270C127413603 @default.
• W2784631270 hasConceptScore W2784631270C147176958 @default.
• W2784631270 hasConceptScore W2784631270C2776694085 @default.
• W2784631270 hasConceptScore W2784631270C2777286243 @default.
• W2784631270 hasConceptScore W2784631270C2780259306 @default.
• W2784631270 hasConceptScore W2784631270C526805850 @default.
• W2784631270 hasConceptScore W2784631270C71924100 @default.
• W2784631270 hasConceptScore W2784631270C90924648 @default.
• W2784631270 hasLocation W27846312701 @default.
• W2784631270 hasOpenAccess W2784631270 @default.
• W2784631270 hasPrimaryLocation W27846312701 @default.
• W2784631270 hasRelatedWork W1521443381 @default.
• W2784631270 hasRelatedWork W1547265195 @default.
• W2784631270 hasRelatedWork W2021538093 @default.
• W2784631270 hasRelatedWork W2082381438 @default.
• W2784631270 hasRelatedWork W2252388707 @default.
• W2784631270 hasRelatedWork W2314610986 @default.
• W2784631270 hasRelatedWork W2323699235 @default.
• W2784631270 hasRelatedWork W2347248699 @default.
• W2784631270 hasRelatedWork W2363947529 @default.
• W2784631270 hasRelatedWork W2392440519 @default.
• W2784631270 hasRelatedWork W2514436365 @default.
• W2784631270 hasRelatedWork W2549359586 @default.
• W2784631270 hasRelatedWork W2999783889 @default.
• W2784631270 hasRelatedWork W3030615807 @default.
• W2784631270 hasRelatedWork W3032173174 @default.
• W2784631270 hasRelatedWork W3199016272 @default.
• W2784631270 hasRelatedWork W3210804117 @default.
• W2784631270 hasRelatedWork W310731336 @default.
• W2784631270 hasRelatedWork W3146516885 @default.
• W2784631270 hasRelatedWork W3146672620 @default.
• W2784631270 isParatext "false" @default.
• W2784631270 isRetracted "false" @default.
• W2784631270 magId "2784631270" @default.
• W2784631270 workType "article" @default.