FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2784821247> ?p ?o ?g. }

• W2784821247 abstract "Abstract Introduction In middle age, declines in executive functioning (EF) are associated with decrements in the quality and/or quantity of white and grey matter. Recruitment of homologous regions has been identified as a compensatory mechanism for cognitive decline in later middle age, however research into neural substrates of EF has yet to be guided by dedifferentiation models. We hypothesized that frontal-parietal grey matter volume, interhemispheric white matter and intrahemispheric white matter fractional anisotropy (FA) will be predictive of EF. Further, we hypothesized that the comparative association between interhemispheric white matter and EF will increase with age, because of compensatory recruitment. Methods Neurocognitive test data, DTI, and T1 MPRAGE scans ( n = 444) were obtained from the NKI-Rockland Sample. Structural equation modeling was used to examine the relationship between age, EF, interhemispheric white matter (forceps minor; FM), intrahemispheric white matter (superior longitudinal fasciculus; SLF), and a frontal-parietal grey matter network. EF and grey matter were modelled as latent variables, with EF examined as the criterion. Additionally, a subsample of participants aged 55-85 ( n = 168) was analyzed to examine the influence of age related compensatory mechanisms. Results There was a significant relationship between FM, grey matter, and EF, which was fully mediated by age. There was a significant relationship between SLF and EF, which was not mediated by age. For older adults, only the age-mediated pathway from FM to EF was significant. Discussion Using structural imaging data, support was found for age-related interhemispheric mechanisms of compensation, but not intrahemispheric mechanisms. Key points (1) Neural substrates of executive functioning are not static across the lifespan. (2) In older adults, white matter becomes more salient as a structural correlate of executive functioning, as recruitment needs increase. (3) While the importance of interhemispheric white matter is mediated by age, intrahemispheric recruitment remains consistent across the lifespan, and is not the primary mechanism of age-based compensation in community dwelling older adults." @default.
• W2784821247 created "2018-02-02" @default.
• W2784821247 creator A5075327295 @default.
• W2784821247 creator A5082731627 @default.
• W2784821247 creator A5091839713 @default.
• W2784821247 date "2017-11-30" @default.
• W2784821247 modified "2023-09-25" @default.
• W2784821247 title "On the Impact of Interhemispheric White Matter: Age, Executive Functioning, and Dedifferentiation in the Frontal Lobes" @default.
• W2784821247 cites W1591978608 @default.
• W2784821247 cites W1965086680 @default.
• W2784821247 cites W1967333153 @default.
• W2784821247 cites W1969210737 @default.
• W2784821247 cites W1971440513 @default.
• W2784821247 cites W1974288685 @default.
• W2784821247 cites W1978165201 @default.
• W2784821247 cites W1997093112 @default.
• W2784821247 cites W2000133863 @default.
• W2784821247 cites W2000697043 @default.
• W2784821247 cites W2010217187 @default.
• W2784821247 cites W2019930104 @default.
• W2784821247 cites W2025264833 @default.
• W2784821247 cites W2031157309 @default.
• W2784821247 cites W2038702827 @default.
• W2784821247 cites W2059527915 @default.
• W2784821247 cites W2065483608 @default.
• W2784821247 cites W2067877506 @default.
• W2784821247 cites W2071666535 @default.
• W2784821247 cites W2080613304 @default.
• W2784821247 cites W2085301512 @default.
• W2784821247 cites W2096753835 @default.
• W2784821247 cites W2097830253 @default.
• W2784821247 cites W2101800098 @default.
• W2784821247 cites W2102421968 @default.
• W2784821247 cites W2105337517 @default.
• W2784821247 cites W2112518510 @default.
• W2784821247 cites W2115744692 @default.
• W2784821247 cites W2117800611 @default.
• W2784821247 cites W2132312934 @default.
• W2784821247 cites W2139581313 @default.
• W2784821247 cites W2142059961 @default.
• W2784821247 cites W2142796869 @default.
• W2784821247 cites W2146437136 @default.
• W2784821247 cites W2148027524 @default.
• W2784821247 cites W2151179877 @default.
• W2784821247 cites W2156466649 @default.
• W2784821247 cites W2168551754 @default.
• W2784821247 cites W2170467533 @default.
• W2784821247 cites W2170684975 @default.
• W2784821247 cites W2500506805 @default.
• W2784821247 cites W4211081781 @default.
• W2784821247 cites W4231652925 @default.
• W2784821247 cites W4242811236 @default.
• W2784821247 cites W4249128071 @default.
• W2784821247 doi "https://doi.org/10.1101/226845" @default.
• W2784821247 hasPublicationYear "2017" @default.
• W2784821247 type Work @default.
• W2784821247 sameAs 2784821247 @default.
• W2784821247 citedByCount "0" @default.
• W2784821247 crossrefType "posted-content" @default.
• W2784821247 hasAuthorship W2784821247A5075327295 @default.
• W2784821247 hasAuthorship W2784821247A5082731627 @default.
• W2784821247 hasAuthorship W2784821247A5091839713 @default.
• W2784821247 hasBestOaLocation W27848212471 @default.
• W2784821247 hasConcept C126838900 @default.
• W2784821247 hasConcept C143409427 @default.
• W2784821247 hasConcept C15744967 @default.
• W2784821247 hasConcept C169760540 @default.
• W2784821247 hasConcept C169900460 @default.
• W2784821247 hasConcept C172467417 @default.
• W2784821247 hasConcept C2777886324 @default.
• W2784821247 hasConcept C2778013878 @default.
• W2784821247 hasConcept C2778183499 @default.
• W2784821247 hasConcept C2781192897 @default.
• W2784821247 hasConcept C548259974 @default.
• W2784821247 hasConcept C71924100 @default.
• W2784821247 hasConcept C89916169 @default.
• W2784821247 hasConceptScore W2784821247C126838900 @default.
• W2784821247 hasConceptScore W2784821247C143409427 @default.
• W2784821247 hasConceptScore W2784821247C15744967 @default.
• W2784821247 hasConceptScore W2784821247C169760540 @default.
• W2784821247 hasConceptScore W2784821247C169900460 @default.
• W2784821247 hasConceptScore W2784821247C172467417 @default.
• W2784821247 hasConceptScore W2784821247C2777886324 @default.
• W2784821247 hasConceptScore W2784821247C2778013878 @default.
• W2784821247 hasConceptScore W2784821247C2778183499 @default.
• W2784821247 hasConceptScore W2784821247C2781192897 @default.
• W2784821247 hasConceptScore W2784821247C548259974 @default.
• W2784821247 hasConceptScore W2784821247C71924100 @default.
• W2784821247 hasConceptScore W2784821247C89916169 @default.
• W2784821247 hasLocation W27848212471 @default.
• W2784821247 hasLocation W27848212472 @default.
• W2784821247 hasOpenAccess W2784821247 @default.
• W2784821247 hasPrimaryLocation W27848212471 @default.
• W2784821247 hasRelatedWork W1984754147 @default.
• W2784821247 hasRelatedWork W2002810039 @default.
• W2784821247 hasRelatedWork W2046294531 @default.
• W2784821247 hasRelatedWork W2162250733 @default.
• W2784821247 hasRelatedWork W2270880665 @default.
• W2784821247 hasRelatedWork W2278270364 @default.
• W2784821247 hasRelatedWork W2566061819 @default.

• next