Matches in SemOpenAlex for { <https://semopenalex.org/work/W2784823525> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2784823525 endingPage "9273" @default.
- W2784823525 startingPage "9269" @default.
- W2784823525 abstract "Interferon/retinoic acid combined with induction of apoptosis related genes (genes associated with retinoid-IFN-induced mortality and GRIMs) is a new apoptosis-related gene family, which is a group of novel cell death regulators with IFN-β combined RA induced expression. In this study, the effects of 9- cis-retinoic acid (RA) on expression of gene associated with retinoid-interferon mortality-1 (GRIM-1) in KM mouse bone cancer tissue were investigated. The transplantable models of bone cancer in KM mice were established to study inhibitory effects of 9-cis-RA against tumor. Immunohistochemical technique was used to analyze the expression of GRIM-1 in KM mouse cancer tissue. The results showed that 9- cis-RA was able to inhibit the growth of bone cancer on mouse at a dose of 650 mg/kg. The expression of GRIM-1 was declined in the mice treated with 9-cis-RA. 9-cis-RA has a significant antitumor effect in vitro. The mechanisms of 9-cis-RA on tumor might associate with down regulating expression of GRIM-1. There was no significant change in the transcriptional level of GRIM-1 in control bone tissue after 9-cis-RA treatment for 24 h. The transcription level of GRIM-1 in bone cancer tissues significantly increased." @default.
- W2784823525 created "2018-02-02" @default.
- W2784823525 creator A5002234993 @default.
- W2784823525 creator A5013357913 @default.
- W2784823525 creator A5031767581 @default.
- W2784823525 creator A5039363991 @default.
- W2784823525 creator A5073748335 @default.
- W2784823525 date "2017-01-01" @default.
- W2784823525 modified "2023-09-23" @default.
- W2784823525 title "The effect of 9-cis-retionic acid on expression of GRIM-1 in KM mouse bone cancer tissue" @default.
- W2784823525 hasPublicationYear "2017" @default.
- W2784823525 type Work @default.
- W2784823525 sameAs 2784823525 @default.
- W2784823525 citedByCount "0" @default.
- W2784823525 crossrefType "journal-article" @default.
- W2784823525 hasAuthorship W2784823525A5002234993 @default.
- W2784823525 hasAuthorship W2784823525A5013357913 @default.
- W2784823525 hasAuthorship W2784823525A5031767581 @default.
- W2784823525 hasAuthorship W2784823525A5039363991 @default.
- W2784823525 hasAuthorship W2784823525A5073748335 @default.
- W2784823525 hasConcept C104317684 @default.
- W2784823525 hasConcept C121608353 @default.
- W2784823525 hasConcept C150194340 @default.
- W2784823525 hasConcept C153911025 @default.
- W2784823525 hasConcept C190283241 @default.
- W2784823525 hasConcept C203014093 @default.
- W2784823525 hasConcept C2775954498 @default.
- W2784823525 hasConcept C2776178377 @default.
- W2784823525 hasConcept C2781121885 @default.
- W2784823525 hasConcept C502942594 @default.
- W2784823525 hasConcept C54355233 @default.
- W2784823525 hasConcept C86803240 @default.
- W2784823525 hasConcept C96232424 @default.
- W2784823525 hasConceptScore W2784823525C104317684 @default.
- W2784823525 hasConceptScore W2784823525C121608353 @default.
- W2784823525 hasConceptScore W2784823525C150194340 @default.
- W2784823525 hasConceptScore W2784823525C153911025 @default.
- W2784823525 hasConceptScore W2784823525C190283241 @default.
- W2784823525 hasConceptScore W2784823525C203014093 @default.
- W2784823525 hasConceptScore W2784823525C2775954498 @default.
- W2784823525 hasConceptScore W2784823525C2776178377 @default.
- W2784823525 hasConceptScore W2784823525C2781121885 @default.
- W2784823525 hasConceptScore W2784823525C502942594 @default.
- W2784823525 hasConceptScore W2784823525C54355233 @default.
- W2784823525 hasConceptScore W2784823525C86803240 @default.
- W2784823525 hasConceptScore W2784823525C96232424 @default.
- W2784823525 hasIssue "21" @default.
- W2784823525 hasLocation W27848235251 @default.
- W2784823525 hasOpenAccess W2784823525 @default.
- W2784823525 hasPrimaryLocation W27848235251 @default.
- W2784823525 hasRelatedWork W1501151562 @default.
- W2784823525 hasRelatedWork W1839349418 @default.
- W2784823525 hasRelatedWork W1981315061 @default.
- W2784823525 hasRelatedWork W2032114319 @default.
- W2784823525 hasRelatedWork W2062292078 @default.
- W2784823525 hasRelatedWork W2086553650 @default.
- W2784823525 hasRelatedWork W2093507022 @default.
- W2784823525 hasRelatedWork W2148676014 @default.
- W2784823525 hasRelatedWork W2313957270 @default.
- W2784823525 hasRelatedWork W2325749759 @default.
- W2784823525 hasRelatedWork W2727290711 @default.
- W2784823525 hasRelatedWork W2748175825 @default.
- W2784823525 hasRelatedWork W2755019806 @default.
- W2784823525 hasRelatedWork W2762584378 @default.
- W2784823525 hasRelatedWork W2763165087 @default.
- W2784823525 hasRelatedWork W2810308689 @default.
- W2784823525 hasRelatedWork W2889681007 @default.
- W2784823525 hasRelatedWork W3087121338 @default.
- W2784823525 hasRelatedWork W3138325783 @default.
- W2784823525 hasRelatedWork W3180697236 @default.
- W2784823525 hasVolume "28" @default.
- W2784823525 isParatext "false" @default.
- W2784823525 isRetracted "false" @default.
- W2784823525 magId "2784823525" @default.
- W2784823525 workType "article" @default.