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- W2784860520 abstract "The intention of this book is to provide a simple, verifiable understanding of evolution of life on earth. The argument, at its core, is frighteningly simple: (1) our “designs” are surprisingly simple and not obviously “intelligent”; (2) RNA synthesis describes evolution; (3) evolution describes RNA synthesis; and (4) evolution of seemingly overly complex protein synthesis systems can be simply modeled. Therefore, evolution can be viewed by understanding mechanisms of RNA and protein syntheses. Before DNA genomes, life passed through a strange RNA-protein world. RNA-template-dependent RNA polymerases of the two double-Ψ–β-barrel types (described in detail in this book) became the dominant enzymes for RNA synthesis. As life evolved into the DNA-template world, these enzymes evolved to become DNA-template-dependent RNA polymerases and spread to all cellular life. RNA, therefore, was and is the central coding molecule of life on earth and remains the intermediary between DNA genomes and protein catalysts. Because life comes from an RNA-protein world, mechanisms for RNA synthesis remain at the heart of life processes, and understanding RNA synthesis is a key to understand evolution." @default.
- W2784860520 created "2018-02-02" @default.
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- W2784860520 date "2018-01-01" @default.
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- W2784860520 title "What This Book Is About" @default.
- W2784860520 doi "https://doi.org/10.1016/b978-0-12-813033-9.00002-0" @default.
- W2784860520 hasPublicationYear "2018" @default.
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