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- W2784909629 endingPage "1751" @default.
- W2784909629 startingPage "1741" @default.
- W2784909629 abstract "The bulk cell population response to a stimulus, be it a growth factor or a cytotoxic agent, neglects the cell-to-cell variability that can serve as a friend or as a foe in human biology. Biochemical variations among closely related cells furnish the basis for the adaptability of the immune system but also act as the root cause of resistance to chemotherapy by tumors. Consequently, the ability to probe for the presence of key biochemical variables at the single-cell level is now recognized to be of significant biological and biomedical impact. Chemical cytometry has emerged as an ultrasensitive single-cell platform with the flexibility to measure an array of cellular components, ranging from metabolite concentrations to enzyme activities. We briefly review the various chemical cytometry strategies, including recent advances in reporter design, probe and metabolite separation, and detection instrumentation. We also describe strategies for improving intracellular delivery, biochemical specificity, metabolic stability, and detection sensitivity of probes. Recent applications of these strategies to small molecules, lipids, proteins, and other analytes are discussed. Finally, we assess the current scope and limitations of chemical cytometry and discuss areas for future development to meet the needs of single-cell research." @default.
- W2784909629 created "2018-02-02" @default.
- W2784909629 creator A5038574360 @default.
- W2784909629 creator A5048509828 @default.
- W2784909629 creator A5058920930 @default.
- W2784909629 creator A5065068715 @default.
- W2784909629 creator A5087890153 @default.
- W2784909629 date "2018-01-27" @default.
- W2784909629 modified "2023-09-25" @default.
- W2784909629 title "Design and Application of Sensors for Chemical Cytometry" @default.
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