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- W2784997672 abstract "Conventional risk factors have been shown to be moderately effective in predicting outcomes in patients with cardiovascular disease. However, up to 20% of patients who present with cardiovascular disease have no traditional risk factors. 1 Substantial efforts to improve our ability to recognize patients with cardiovascular disease at earlier stages have included identification of “biomarkers.” These biomarkers, usually in the form of a blood test, represent objective measurements of a particular biologic process considered important in the pathogenesis of the disease of interest. Thus, cardiac biomarkers are used to predict or prognosticate the presence or severity of a cardiac condition, and have been proposed to supplement conventional risk factors. Several biomarkers have been incorporated into well known risk scores and provide improved prognostication into higher and lower risk groups. 2,3 The most well known biomarkers include: high-sensitivity C-reactive protein (hs-CRP)d am arker of inflammation; albuminuriada marker of renal dysfunction; troponinda marker of cardiac damage; brain natriuretic protein (BNP)dvolume overload; and fibrinogend am arker of the coagulation cascade. An ideal biomarker should be inexpensive, easy to measure, stable in plasma, serum, and blood samples, accurately differentiate patient outcomes, and help guide the treatment of a specific patient. Several new cardiac biomarkers have been identified in recent years, including some in widespread use (eg, inflammation, volume overload, oxidative stress, apoptosis). Some have gained widespread use (eg, BNP and albuminuria). However, even common biomarkers such as hs-CRP and endothelial function markers have not gained general acceptance because of cost issues, logistic concerns, or lack of studies that show effects on hard clinical end points. Recently, multimarker strategies in studies that incorporate several biomarkers have been shown to improve their ability to predict future major cardiac events. 4,5" @default.
- W2784997672 created "2018-02-02" @default.
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- W2784997672 date "2015-01-01" @default.
- W2784997672 modified "2023-09-27" @default.
- W2784997672 title "Editorial suPAR: A Cardiac Biomarker With a Future?" @default.
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