FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2785014080> ?p ?o ?g. }

• W2785014080 abstract "Aim To investigate expression of cell cycle-related and expression-elevated protein in tumor (CREPT) in colorectal cancer (CRC) and determine its prognostic value in response to 5-fluorouracil (5-FU). Methods The relative expression of CREPT in CRC tumor samples was determined using immunohistochemistry. The protein content in cell lines was analyzed by immunoblotting. Cell viability was measured with the CCK-8 assay. Cell cycle and apoptosis analyses were performed with flow cytometry. Results CREPT was overexpressed in CRC tissues and correlated with histological grade. Clinicopathological analysis indicated that CREPT was positively related to tumor progression. Exogenous expression of CREPT stimulated cell proliferation and accelerated the cell cycle. More importantly, high expression of CREPT sensitized CRC cells to 5-FU treatment. Furthermore, we demonstrated that 5-FU elicited significant apoptosis in CREPT-positive cells. Conclusion Aberrant overexpression of CREPT contributes to tumorigenesis of CRC by promoting cell proliferation and accelerating the cell cycle, and confers sensitivity to 5-FU. CREPT is a potential prognostic biomarker for 5-FU in CRC." @default.
• W2785014080 created "2018-02-02" @default.
• W2785014080 creator A5007453059 @default.
• W2785014080 creator A5011287020 @default.
• W2785014080 creator A5018863416 @default.
• W2785014080 creator A5024829119 @default.
• W2785014080 creator A5025651686 @default.
• W2785014080 creator A5029667848 @default.
• W2785014080 creator A5031169806 @default.
• W2785014080 creator A5032244728 @default.
• W2785014080 creator A5043427543 @default.
• W2785014080 creator A5048489681 @default.
• W2785014080 creator A5061530426 @default.
• W2785014080 creator A5074200075 @default.
• W2785014080 creator A5085749968 @default.
• W2785014080 date "2018-01-28" @default.
• W2785014080 modified "2023-09-22" @default.
• W2785014080 title "Overexpression of CREPT confers colorectal cancer sensitivity to fluorouracil" @default.
• W2785014080 cites W1967218392 @default.
• W2785014080 cites W1984328540 @default.
• W2785014080 cites W1995044677 @default.
• W2785014080 cites W2020212248 @default.
• W2785014080 cites W2024756742 @default.
• W2785014080 cites W2044825095 @default.
• W2785014080 cites W2139002359 @default.
• W2785014080 cites W2143483834 @default.
• W2785014080 cites W2167508669 @default.
• W2785014080 cites W2272984102 @default.
• W2785014080 cites W2302432897 @default.
• W2785014080 cites W2536766940 @default.
• W2785014080 cites W2604697276 @default.
• W2785014080 cites W2614067350 @default.
• W2785014080 cites W2620625781 @default.
• W2785014080 cites W2728184191 @default.
• W2785014080 cites W2730004669 @default.
• W2785014080 cites W4211199921 @default.
• W2785014080 doi "https://doi.org/10.3748/wjg.v24.i4.475" @default.
• W2785014080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5787782" @default.
• W2785014080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29398868" @default.
• W2785014080 hasPublicationYear "2018" @default.
• W2785014080 type Work @default.
• W2785014080 sameAs 2785014080 @default.
• W2785014080 citedByCount "9" @default.
• W2785014080 countsByYear W27850140802019 @default.
• W2785014080 countsByYear W27850140802020 @default.
• W2785014080 countsByYear W27850140802021 @default.
• W2785014080 countsByYear W27850140802023 @default.
• W2785014080 crossrefType "journal-article" @default.
• W2785014080 hasAuthorship W2785014080A5007453059 @default.
• W2785014080 hasAuthorship W2785014080A5011287020 @default.
• W2785014080 hasAuthorship W2785014080A5018863416 @default.
• W2785014080 hasAuthorship W2785014080A5024829119 @default.
• W2785014080 hasAuthorship W2785014080A5025651686 @default.
• W2785014080 hasAuthorship W2785014080A5029667848 @default.
• W2785014080 hasAuthorship W2785014080A5031169806 @default.
• W2785014080 hasAuthorship W2785014080A5032244728 @default.
• W2785014080 hasAuthorship W2785014080A5043427543 @default.
• W2785014080 hasAuthorship W2785014080A5048489681 @default.
• W2785014080 hasAuthorship W2785014080A5061530426 @default.
• W2785014080 hasAuthorship W2785014080A5074200075 @default.
• W2785014080 hasAuthorship W2785014080A5085749968 @default.
• W2785014080 hasBestOaLocation W27850140801 @default.
• W2785014080 hasConcept C121608353 @default.
• W2785014080 hasConcept C126322002 @default.
• W2785014080 hasConcept C142724271 @default.
• W2785014080 hasConcept C1491633281 @default.
• W2785014080 hasConcept C185592680 @default.
• W2785014080 hasConcept C190283241 @default.
• W2785014080 hasConcept C203014093 @default.
• W2785014080 hasConcept C204232928 @default.
• W2785014080 hasConcept C2781197716 @default.
• W2785014080 hasConcept C29537977 @default.
• W2785014080 hasConcept C502942594 @default.
• W2785014080 hasConcept C526805850 @default.
• W2785014080 hasConcept C553184892 @default.
• W2785014080 hasConcept C55493867 @default.
• W2785014080 hasConcept C555283112 @default.
• W2785014080 hasConcept C62112901 @default.
• W2785014080 hasConcept C71924100 @default.
• W2785014080 hasConceptScore W2785014080C121608353 @default.
• W2785014080 hasConceptScore W2785014080C126322002 @default.
• W2785014080 hasConceptScore W2785014080C142724271 @default.
• W2785014080 hasConceptScore W2785014080C1491633281 @default.
• W2785014080 hasConceptScore W2785014080C185592680 @default.
• W2785014080 hasConceptScore W2785014080C190283241 @default.
• W2785014080 hasConceptScore W2785014080C203014093 @default.
• W2785014080 hasConceptScore W2785014080C204232928 @default.
• W2785014080 hasConceptScore W2785014080C2781197716 @default.
• W2785014080 hasConceptScore W2785014080C29537977 @default.
• W2785014080 hasConceptScore W2785014080C502942594 @default.
• W2785014080 hasConceptScore W2785014080C526805850 @default.
• W2785014080 hasConceptScore W2785014080C553184892 @default.
• W2785014080 hasConceptScore W2785014080C55493867 @default.
• W2785014080 hasConceptScore W2785014080C555283112 @default.
• W2785014080 hasConceptScore W2785014080C62112901 @default.
• W2785014080 hasConceptScore W2785014080C71924100 @default.
• W2785014080 hasLocation W27850140801 @default.
• W2785014080 hasLocation W27850140802 @default.
• W2785014080 hasLocation W27850140803 @default.
• W2785014080 hasOpenAccess W2785014080 @default.

• next