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• W2785127718 abstract "DNA methylation has a potential role in controlling gene expression and may, therefore, contribute to salinity adaptation in plants. Caliph medic (Medicago truncatula) is a model legume of moderate salinity tolerance capacity; however, a base-resolution DNA methylome map is not yet available for this plant. In this report, a differential whole-genome bisulfite sequencing (WGBS) was carried out using DNA samples extracted from root tissues exposed to either control or saline conditions. Around 50 million differentially methylated sites (DMSs) were recognized, 7% of which were significantly (p < 0.05, FDR < 0.05) altered in response to salinity. This analysis showed that 77.0% of the contexts of DMSs were mCHH, while only 9.1% and 13.9% were mCHG and mCG, respectively. The average change in methylation level was increased in all sequence contexts, ranging from 3.8 to 10.2% due to salinity stress. However, collectively, the level of the DNA methylation in the gene body slightly decreased in response to salinity treatment. The global increase in DNA methylation due to salinity was confirmed by mass spectrometry analysis. Gene expression analysis using qPCR did not reveal a constant relationship between the level of mCG methylation and the transcription abundance of some genes of potential importance in salinity tolerance, such as the potassium channel KAT3, the vacuolar H+-pyrophosphatase (V-PPase), and the AP2/ERF and bZIP transcription factors, implying the involvement of other epigenetic gene expression controllers. Computational functional prediction of the annotated genes that embrace DMSs revealed the presence of enzymes with potential cellular functions in biological processes associated with salinity tolerance mechanisms. The information obtained from this study illustrates the effect of salinity on DNA methylation and shows how plants can remodel the landscape of 5-methylcytosine nucleotide (5-mC) in the DNA across gene structures, in response to salinity. This remodeling varies between gene regions and between 5-mC sequence contexts. The mCG has a vague impact on the expression levels of a few selected potentially important genes in salt tolerant mechanisms." @default.
• W2785127718 created "2018-02-02" @default.
• W2785127718 creator A5013490838 @default.
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• W2785127718 creator A5038104861 @default.
• W2785127718 date "2018-01-24" @default.
• W2785127718 modified "2023-10-10" @default.
• W2785127718 title "Genome-wide DNA Methylation analysis in response to salinity in the model plant caliph medic (Medicago truncatula)" @default.
• W2785127718 cites W1519629411 @default.
• W2785127718 cites W1635138836 @default.
• W2785127718 cites W1669374546 @default.
• W2785127718 cites W1966728201 @default.
• W2785127718 cites W1973824858 @default.
• W2785127718 cites W1974116356 @default.
• W2785127718 cites W1985542606 @default.
• W2785127718 cites W1989548642 @default.
• W2785127718 cites W1993485956 @default.
• W2785127718 cites W1995967026 @default.
• W2785127718 cites W1996649001 @default.
• W2785127718 cites W1997796525 @default.
• W2785127718 cites W1999348612 @default.
• W2785127718 cites W2005458309 @default.
• W2785127718 cites W2015456365 @default.
• W2785127718 cites W2016813268 @default.
• W2785127718 cites W2019197788 @default.
• W2785127718 cites W2024848067 @default.
• W2785127718 cites W2026343134 @default.
• W2785127718 cites W2027125490 @default.
• W2785127718 cites W2031418162 @default.
• W2785127718 cites W2038725011 @default.
• W2785127718 cites W2038962661 @default.
• W2785127718 cites W2048780048 @default.
• W2785127718 cites W2050507681 @default.
• W2785127718 cites W2051406511 @default.
• W2785127718 cites W2056881310 @default.
• W2785127718 cites W2059979506 @default.
• W2785127718 cites W2064155145 @default.
• W2785127718 cites W2064826808 @default.
• W2785127718 cites W2078028724 @default.
• W2785127718 cites W2082142840 @default.
• W2785127718 cites W2085561926 @default.
• W2785127718 cites W2087661216 @default.
• W2785127718 cites W2089294142 @default.
• W2785127718 cites W2091722627 @default.
• W2785127718 cites W2093896423 @default.
• W2785127718 cites W2101920472 @default.
• W2785127718 cites W2104882487 @default.
• W2785127718 cites W2105286253 @default.
• W2785127718 cites W2107277218 @default.
• W2785127718 cites W2107337799 @default.
• W2785127718 cites W2110556684 @default.
• W2785127718 cites W2111024822 @default.
• W2785127718 cites W2113202990 @default.
• W2785127718 cites W2115476123 @default.
• W2785127718 cites W2117229776 @default.
• W2785127718 cites W2121314501 @default.
• W2785127718 cites W2128653886 @default.
• W2785127718 cites W2131374955 @default.
• W2785127718 cites W2133289818 @default.
• W2785127718 cites W2134980868 @default.
• W2785127718 cites W2142237411 @default.
• W2785127718 cites W2149206894 @default.
• W2785127718 cites W2149254097 @default.
• W2785127718 cites W2152955481 @default.
• W2785127718 cites W2153160772 @default.
• W2785127718 cites W2158804744 @default.
• W2785127718 cites W2159699532 @default.
• W2785127718 cites W2161980634 @default.
• W2785127718 cites W2166202788 @default.
• W2785127718 cites W2168420558 @default.
• W2785127718 cites W2168684626 @default.
• W2785127718 cites W2171644358 @default.
• W2785127718 cites W2174202543 @default.
• W2785127718 cites W2192080449 @default.
• W2785127718 cites W2225514865 @default.
• W2785127718 cites W2233416065 @default.
• W2785127718 cites W2277434072 @default.
• W2785127718 cites W2289422509 @default.
• W2785127718 cites W2299608576 @default.
• W2785127718 cites W2338380910 @default.
• W2785127718 cites W2414822706 @default.
• W2785127718 cites W2542103360 @default.
• W2785127718 cites W2598046389 @default.
• W2785127718 cites W2609359678 @default.
• W2785127718 cites W2738558790 @default.
• W2785127718 cites W2739224539 @default.
• W2785127718 cites W2768748598 @default.
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• W2785127718 doi "https://doi.org/10.1186/s12864-018-4484-5" @default.
• W2785127718 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5781308" @default.
• W2785127718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29361906" @default.
• W2785127718 hasPublicationYear "2018" @default.
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